Immunohistochemistry (IHC)
(Anti-WNT10B antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit WNT10B Polyclonal Antibody | anti-WNT10B antibody
Rabbit Polyclonal to Human WNT10B
Predicted Reactivity: Monkey, Horse, Rabbit (at least 90% immunogen sequence identity)
Predicted Reactivity: Monkey, Horse, Rabbit (at least 90% immunogen sequence identity)
Immunohistochemistry (IHC)
(Anti-WNT10B antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-WNT10B antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
NCBI and Uniprot Product Information
NCBI Description
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
Uniprot Description
WNT10B: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Defects in WNT10B are the cause of split-hand/foot malformation type 6 (SHFM6). SHFM is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. SHFM6 is a autosomal recessive disorder. Belongs to the Wnt family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region
Molecular Function: frizzled binding; receptor agonist activity
Biological Process: positive regulation of apoptosis; skeletal muscle fiber development; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; positive regulation of cell proliferation; positive regulation of epithelial cell differentiation; chondrocyte differentiation; G2/M transition of mitotic cell cycle; cell cycle arrest; positive regulation of transcriptional preinitiation complex assembly; negative regulation of epithelial cell proliferation; smoothened signaling pathway; Wnt receptor signaling pathway; cell fate commitment; sensory perception of taste; protein stabilization; regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of fat cell differentiation; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; regulation of skeletal muscle development; positive regulation of transcription factor activity; lipid metabolic process; positive regulation of anagen; myoblast cell differentiation involved in skeletal muscle regeneration
Disease: Split-hand/foot Malformation 6
Research Articles on WNT10B
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Product Notes
The WNT10B wnt10b (Catalog #AAA244473) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human WNT10B reacts with Bat, Gibbon, Dog, Gorilla, Hamster, Human, Mouse, Orangutan, Pig, Rat Predicted Reactivity: Monkey, Horse, Rabbit (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's WNT10B can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (5 ug/ml). Researchers should empirically determine the suitability of the WNT10B wnt10b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "WNT10B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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