Rabbit GPRC6A Polyclonal Antibody | anti-GPRC6A antibody

Rabbit Polyclonal to Human GPRC6A

Cat. Num. AAA243378

• Gene Names: GPRC6A; GPCR; bA86F4.3
• Reactivity: Gorilla, Human, Monkey; Predicted Reactivity: Dog, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GPRC6A; Polyclonal Antibody; Rabbit Polyclonal to Human GPRC6A; Anti-GPRC6A Antibody (N-Terminus) IHC-plus; BA86F4.3; HGPCR33; HGPRC6A; Predicted with SOSUI analysis; Human GPRC6A; anti-GPRC6A antibody

• Host: Rabbit
• Reactivity: Gorilla, Human, Monkey; Predicted Reactivity: Dog, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human GPRC6A. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except NBPF3 (59%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 926

• Applicable Applications for anti-GPRC6A antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (11 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GPRC6A. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Panda (100%); Dog, Elephant, Rabbit, Horse, Pig (94%).
• Immunogen Type: Synthetic peptide
• Immunogen: GPRC6A antibody was raised against synthetic 17 amino acid peptide from N-terminal extracellular domain of human GPRC6A. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Panda (100%); Dog, Elephant, Rabbit, Horse, Pig (94%); Marmoset, Mouse, Rat, Bovine, Hamster (82%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-GPRC6A antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPRC6A antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-GPRC6A antibody

GPRC6A has been shown to bind to L-alpha-amino acids. Recently GPRC6A has been suggested to be a calcium-sensing receptor (Pi et al. 2005).

Product Categories/Family for anti-GPRC6A antibody

Family: GPCR; Subfamily: Amino Acid Receptor

NCBI and Uniprot Product Information

• NCBI GI #: 112807234
• NCBI GeneID: 222545
• NCBI Accession #: NP_683766.2
• NCBI GenBank Nucleotide #: NM_148963.3
• UniProt Accession #: Q5T6X5; Q6JK43; Q6JK44; Q8NGU8; Q8NHZ9; Q8TDT6
• Molecular Weight: 96,526 Da
• NCBI Official Full Name: G-protein coupled receptor family C group 6 member A isoform 1
• NCBI Official Synonym Full Names: G protein-coupled receptor, class C, group 6, member A
• NCBI Official Symbol: GPRC6A
• NCBI Official Synonym Symbols: GPCR; bA86F4.3
• NCBI Protein Information: G-protein coupled receptor family C group 6 member A; predicted with SOSUI analysis; G-protein coupled receptor GPCR33; seven transmembrane helix receptor; G protein-coupled receptor, family C, group 6, member A
• UniProt Protein Name: G-protein coupled receptor family C group 6 member A
• Protein Family: G-protein coupled receptor family
• UniProt Gene Name: GPRC6A
• UniProt Synonym Gene Names: hGPRC6A; hGPCR33
• UniProt Entry Name: GPC6A_HUMAN

NCBI Description

Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]

Uniprot Description

GPRC6A: Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids. Belongs to the G-protein coupled receptor 3 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 3; Receptor, GPCR

Chromosomal Location of Human Ortholog: 6q22.1

Cellular Component: cell surface; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; calcium-mediated signaling; response to amino acid stimulus