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Immunohistochemistry (IHC) (Anti-PACE4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Rabbit PACE4 / PCSK6 Polyclonal Antibody | anti-PACE4 antibody

Rabbit Polyclonal to Human PACE4 / PCSK6

Gene Names
PCSK6; SPC4; PACE4
Reactivity
Bovine, Gorilla, Horse, Human, Monkey, Rabbit, Rat
Predicted Reactivity: Gibbon, Mouse, Dog, Pig (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry, ELISA
Purity
Immunoaffinity Purified
Synonyms
PACE4 / PCSK6; Polyclonal Antibody; Rabbit Polyclonal to Human PACE4 / PCSK6; Anti-PACE4 / PCSK6 Antibody (Internal) IHC-plus; PCSK6; PACE4; SPC4; Human PACE4; anti-PACE4 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Bovine, Gorilla, Horse, Human, Monkey, Rabbit, Rat
Predicted Reactivity: Gibbon, Mouse, Dog, Pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human PACE4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
969
Applicable Applications for anti-PACE4 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes
ELISA, IHC-P (10 ug/ml)
Usage: Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.
Target Species
Human
Immunogen Description
Synthetic 14 amino acid peptide from Cys-rich motif (CRM) region of human PACE4. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Rat, Bovine, Elephant, Horse, Rabbit (100%); Gibbon, Mouse, Dog, Panda.
Immunogen Type
Synthetic peptide
Immunogen
PACE4 / PCSK6 antibody was raised against synthetic 14 amino acid peptide from Cys-rich motif (CRM) region of human PACE4. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Rat, Bovine, Elephant, Horse, Rabbit (100%); Gibbon, Mouse, Dog, Panda, Pig (93%); Turkey, Chicken (86%).
Antigen Modification
Internal
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-PACE4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-PACE4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-PACE4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-PACE4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-PACE4 antibody
PACE4 is a Serine S8 type protease that cleaves precursor proteins at paired basic amino acid processing sites. Several PACE4 substrates have been identified, including transforming growth factor beta-related proteins, proalbumin and von Willebrand factor. At least eight alternatively spliced transcript variants encoding different isoforms have been reported. In mouse, PACE4 has been shown to increase tumor cell invasiveness, and thus enhance tumor progression.
Product Categories/Family for anti-PACE4 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
105,375 Da
NCBI Official Full Name
proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein
NCBI Official Synonym Full Names
proprotein convertase subtilisin/kexin type 6
NCBI Official Symbol
PCSK6
NCBI Official Synonym Symbols
SPC4; PACE4
NCBI Protein Information
proprotein convertase subtilisin/kexin type 6; subtilisin/kexin-like protease PACE4; subtilisin-like proprotein convertase 4; paired basic amino acid cleaving enzyme 4; paired basic amino acid cleaving system 4
UniProt Protein Name
Proprotein convertase subtilisin/kexin type 6
UniProt Gene Name
PCSK6
UniProt Synonym Gene Names
PACE4; SPC4
UniProt Entry Name
PCSK6_HUMAN

NCBI Description

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]

Uniprot Description

PCSK6: Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif. Belongs to the peptidase S8 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Protease; Secreted, signal peptide; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: extracellular matrix; extracellular space; cell surface; membrane; Golgi lumen; endoplasmic reticulum

Molecular Function: heparin binding; serine-type endopeptidase activity; endopeptidase activity; nerve growth factor binding

Biological Process: nerve growth factor processing; glycoprotein metabolic process; zygotic determination of anterior/posterior axis, embryo; nerve growth factor receptor signaling pathway; peptide hormone processing; regulation of BMP signaling pathway; protein processing; determination of left/right symmetry; proteolysis; nerve growth factor production; secretion by cell

Research Articles on PACE4

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Product Notes

The PACE4 pcsk6 (Catalog #AAA242327) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human PACE4 / PCSK6 reacts with Bovine, Gorilla, Horse, Human, Monkey, Rabbit, Rat Predicted Reactivity: Gibbon, Mouse, Dog, Pig (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's PACE4 / PCSK6 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), ELISA (EIA). ELISA, IHC-P (10 ug/ml) Usage: Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K. Researchers should empirically determine the suitability of the PACE4 pcsk6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PACE4 / PCSK6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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