Goat anti-Human PCSK6 Polyclonal Antibody | anti-PCSK6 antibody

PCSK6, ID (PACE4, Proprotein Convertase Subtilisin/Kexin Type 6, Paired Basic Amino Acid Cleaving Enzyme 4, Subtilisin-like Proprotein Convertase 4, SPC4, Subtilisin/Kexin-like Protease PACE4)

Cat. Num. AAA6000495

• Gene Names: PCSK6; SPC4; PACE4
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: PCSK6; Polyclonal Antibody; ID (PACE4; Proprotein Convertase Subtilisin/Kexin Type 6; Paired Basic Amino Acid Cleaving Enzyme 4; Subtilisin-like Proprotein Convertase 4; SPC4; Subtilisin/Kexin-like Protease PACE4); Anti -PCSK6; anti-PCSK6 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human PCSK6. Species sequence homology: mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-PCSK6 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:8000; Immunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml
• Immunogen: Synthetic peptide PDCEPGTYFDSE from an internal region of human PCSK6.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-PCSK6 antibody

PACE4 is a Serine S8 type protease that cleaves precursor proteins at paired basic amino acid processing sites. Several PACE4 substrates have been identified, including transforming growth factor beta-related proteins, proalbumin and von Willebrand factor. At least eight alternatively spliced transcript variants encoding different isoforms have been reported. In mouse, PACE4 has been shown to increase tumor cell invasiveness, and thus enhance tumor progression.

Product Categories/Family for anti-PCSK6 antibody

Antibodies; Abs to Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 20336188
• NCBI GeneID: 5046
• NCBI Accession #: NP_612196.1
• NCBI GenBank Nucleotide #: NM_138323.1
• UniProt Accession #: P29122; Q15099; Q15100; Q9UEG7; Q9UEJ1; Q9UEJ2; Q9UEJ7; Q9UEJ8; Q9UEJ9; Q9Y4G9; Q9Y4H0; Q9Y4H1
• Molecular Weight: 106,420 Da
• NCBI Official Full Name: proprotein convertase subtilisin/kexin type 6 isoform e preproprotein
• NCBI Official Synonym Full Names: proprotein convertase subtilisin/kexin type 6
• NCBI Official Symbol: PCSK6
• NCBI Official Synonym Symbols: SPC4; PACE4
• NCBI Protein Information: proprotein convertase subtilisin/kexin type 6; subtilisin/kexin-like protease PACE4; subtilisin-like proprotein convertase 4; paired basic amino acid cleaving enzyme 4; paired basic amino acid cleaving system 4
• UniProt Protein Name: Proprotein convertase subtilisin/kexin type 6
• Protein Family: Proprotein convertase subtilisin/kexin
• UniProt Gene Name: PCSK6
• UniProt Synonym Gene Names: PACE4; SPC4
• UniProt Entry Name: PCSK6_HUMAN

NCBI Description

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

PCSK6: Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif. Belongs to the peptidase S8 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; EC 3.4.21.-; Protease

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: extracellular matrix; extracellular space; cell surface; membrane; endoplasmic reticulum; Golgi lumen

Molecular Function: heparin binding; serine-type endopeptidase activity; endopeptidase activity; nerve growth factor binding

Biological Process: nerve growth factor processing; nerve growth factor receptor signaling pathway; glycoprotein metabolic process; zygotic determination of anterior/posterior axis, embryo; peptide hormone processing; regulation of BMP signaling pathway; protein processing; determination of left/right symmetry; proteolysis; nerve growth factor production; secretion by cell