Immunohistochemistry (IHC)
(Human Small Intestine, Myenteric Plecus: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit MAPK8IP1/JIP1 Polyclonal Antibody | anti-MAPK8IP1/JIP1 antibody
Anti-MAPK8IP1/JIP1 Antibody (aa69-118)
Predicted: Mouse, Rat
Predicted: Mouse, Rat
IF: 1:100-1:500
IHC-P: 1:50
WB: 1:500-1:1000
Immunohistochemistry (IHC)
(Human Small Intestine, Myenteric Plecus: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry (IHC)
(Human Small Intestine, Myenteric Plecus: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunofluorescence (IF)
(Immunofluorescence of NIH-3T3 cells, using JIP1 Antibody. The sample on the right was incubated with synthetic peptide.)
Immunofluorescence (IF)
(Immunofluorescence of NIH-3T3 cells, using JIP1 Antibody. The sample on the right was incubated with synthetic peptide.)
Western Blot (WB)
(Western blot of extracts from COLO205 cells, treated with Serum 20% 15', using JIP1 Antibody. The lane on the right was incubated with synthetic peptide.)
Western Blot (WB)
(Western blot of extracts from COLO205 cells, treated with Serum 20% 15', using JIP1 Antibody. The lane on the right was incubated with synthetic peptide.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
Uniprot Description
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.
Research Articles on MAPK8IP1/JIP1
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Product Notes
The MAPK8IP1/JIP1 mapk8ip1 (Catalog #AAA2401175) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-MAPK8IP1/JIP1 Antibody (aa69-118) reacts with Human Predicted: Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MAPK8IP1/JIP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin, Western Blot (WB). ELISA: 1:5000 IF: 1:100-1:500 IHC-P: 1:50 WB: 1:500-1:1000. Researchers should empirically determine the suitability of the MAPK8IP1/JIP1 mapk8ip1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MAPK8IP1/JIP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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