Goat SLC4A11/NABC1 Polyclonal Antibody | anti-SLC4A11/NABC1 antibody

Anti-SLC4A11/NABC1 Antibody (aa136-150)

Cat. Num. AAA2400841

• Gene Names: SLC4A11; BTR1; CHED; CDPD1; CHED2; NABC1; dJ794I6.2
• Reactivity: Human; Predicted: Monkey
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: SLC4A11/NABC1; Polyclonal Antibody; Anti-SLC4A11/NABC1 Antibody (aa136-150); Rabbit Polyclonal (IgG) to Human SLC4A11/NABC1; SLC4A11; CDPD1; CHED2; FECD4; DJ794I6.2; Sodium borate cotransporter 1; BTR1; CDPD; NABC1; anti-SLC4A11/NABC1 antibody

• Host: Goat
• Reactivity: Human; Predicted: Monkey
• Clonality: Polyclonal
• Specificity: Human SLC4A11.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Sequence Length: 891

• Applicable Applications for anti-SLC4A11/NABC1 antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: ELISA: 1:32000; IHC-P: 3.75 ug/ml; WB: 0.3-1 ug/ml
• Immunogen: Synthetic peptide C-HTSRKYLKLKNFKEE from an internal region of human SLC4A11 (NP_114423.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Hamster, Elephant, Bat, Bovine, Horse, Rabbit, Turkey, Chicken, Xenopus (93%); Dog (80%).
• Conjugation: Unconjugated
• Epitope: aa136-150
• Preparation and Storage: Store at -20 degree C.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-SLC4A11/NABC1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Western Blot (WB)

(SLC4A11 antibody (0.3 ug/ml) staining of Human Kidney lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Related Product Information for anti-SLC4A11/NABC1 antibody

Transporter which plays an important role in sodium-mediated fluidtransport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium throughthe fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation ofpotassium concentrations in the endolymph.

Product Categories/Family for anti-SLC4A11/NABC1 antibody

Transporter; Anion exchanger

NCBI and Uniprot Product Information

• NCBI GI #: 14042960
• NCBI GeneID: 83959
• NCBI Accession #: NP_114423.1
• NCBI GenBank Nucleotide #: NM_032034.3
• UniProt Accession #: Q8NBS3; Q2TB62; Q2TB63; Q9BXF4; Q9NTW9; B4DKC8; B4DKX9; G3V1M3
• Molecular Weight: 103,145 Da
• NCBI Official Full Name: sodium bicarbonate transporter-like protein 11 isoform 2
• NCBI Official Synonym Full Names: solute carrier family 4 member 11
• NCBI Official Symbol: SLC4A11
• NCBI Official Synonym Symbols: BTR1; CHED; CDPD1; CHED2; NABC1; dJ794I6.2
• NCBI Protein Information: sodium bicarbonate transporter-like protein 11
• UniProt Protein Name: Sodium bicarbonate transporter-like protein 11
• UniProt Gene Name: SLC4A11
• UniProt Synonym Gene Names: BTR1; NaBC1

NCBI Description

This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

Uniprot Description

Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (). Involved in borate homeostasis. In the absence of borate, it functions as a Na+ and OH-(H+) channel. In the presence of borate functions as an electrogenic Na+ coupled borate cotransporter.