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Immunohistochemistry (IHC) (Anti-SUZ12 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Rabbit anti-Human SUZ12 Polyclonal Antibody | anti-SUZ12 antibody

Anti-SUZ12 Antibody (Internal) IHC-plus

Gene Names
SUZ12; CHET9; JJAZ1
Reactivity
Human
Applications
Immunohistochemistry, Immunofluorescence, Western Blot, ELISA
Purity
Immunoaffinity purified
Synonyms
SUZ12; Polyclonal Antibody; Anti-SUZ12 Antibody (Internal) IHC-plus; Rabbit Polyclonal (IgG) to Human SUZ12; Human SUZ12; ChET 9 protein; Joined to JAZF1 protein; CHET9; JJAZ1; KIAA0160; Polycomb protein SUZ12; anti-SUZ12 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
SUZ12 antibody is human specific.
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.02% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
739
Applicable Applications for anti-SUZ12 antibody
Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes
IF (20 ug/ml)
IHC-P (10 ug/ml)
WB (1 - 2 ug/ml)
Immunogen
SUZ12 antibody was raised against 19 amino acid peptide near the center of human SUZ12.
Immunogen Description
19 amino acid peptide near the center of human SUZ12.
Antigen Modification
Internal
Target Species
Human
Preparation and Storage
Long term: -20 degree C
Short term: 4 degree C
Avoid repeat freeze-thaw cycles

Immunohistochemistry (IHC)

(Anti-SUZ12 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunohistochemistry (IHC) (Anti-SUZ12 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of SUZ12 in human lung tissue with SUZ12 antibody at 20 µg/mL.)

Immunofluorescence (IF) (Immunofluorescence of SUZ12 in human lung tissue with SUZ12 antibody at 20 µg/mL.)

Western Blot (WB)

(Western blot analysis of SUZ12 in human liver tissue lysate with SUZ12 antibody at 1 ug/ml.)

Western Blot (WB) (Western blot analysis of SUZ12 in human liver tissue lysate with SUZ12 antibody at 1 ug/ml.)
Related Product Information for anti-SUZ12 antibody
SUZ12 Antibody, ChET 9 protein Antibody, Joined to JAZF1 protein Antibody, CHET9 Antibody, JJAZ1 Antibody, KIAA0160 Antibody, Polycomb protein SUZ12 Antibody Description: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
83,055 Da
NCBI Official Full Name
polycomb protein SUZ12
NCBI Official Synonym Full Names
SUZ12 polycomb repressive complex 2 subunit
NCBI Official Symbol
SUZ12
NCBI Official Synonym Symbols
CHET9; JJAZ1
NCBI Protein Information
polycomb protein SUZ12
UniProt Protein Name
Polycomb protein SUZ12
Protein Family
UniProt Gene Name
SUZ12
UniProt Synonym Gene Names
CHET9; JJAZ1; KIAA0160; ChET 9 protein
UniProt Entry Name
SUZ12_HUMAN

NCBI Description

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]

Uniprot Description

SUZ12: a zinc finger protein. A breakpoint translocation of the cognate gene with JAZF1 has been reported in endometrial stromal sarcoma.

Protein type: Transcription factor; Oncoprotein; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: ESC/E(Z) complex; nucleolus; nucleoplasm; nucleus; sex chromatin

Molecular Function: chromatin DNA binding; histone methyltransferase activity; metal ion binding; methylated histone residue binding; protein binding; RNA binding

Biological Process: establishment and/or maintenance of chromatin architecture; gene expression; histone methylation; histone ubiquitination; negative regulation of cell differentiation; negative regulation of gene expression, epigenetic; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; regulation of gene expression, epigenetic; transcription, DNA-dependent

Research Articles on SUZ12

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Product Notes

The SUZ12 suz12 (Catalog #AAA2400188) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SUZ12 Antibody (Internal) IHC-plus reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SUZ12 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA). IF (20 ug/ml) IHC-P (10 ug/ml) WB (1 - 2 ug/ml). Researchers should empirically determine the suitability of the SUZ12 suz12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SUZ12, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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