PYRUVATE KINASE Active Protein | PKM active protein
NATIVE RABBIT PYRUVATE KINASE
Semi purified enzyme from rabbit muscle - lyophilised
Shelf Life: 18 months from date of despatch.
NCBI and Uniprot Product Information
Uniprot Description
PKM2: one of three rate-limiting enzymes in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule ATP and a pyruvate molecule, which is a central metabolic intermediate that can be used as a building block or oxidized further. Overexpressed in a variety of cancers. Interacts with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. Binds Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogens is. There are several mammalian isozymes of pyruvate kinase encoded by different genes. The L type predominates in liver, and the M type in muscle and brain. Two alternatively spliced human isoforms of PKM2 have been reported.
Protein type: Kinase, other; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Nucleotide Metabolism - purine; EC 2.7.1.40; Mitochondrial
Cellular Component: extracellular matrix; mitochondrion; cytoplasm; plasma membrane; nucleus; vesicle; myelin sheath; cilium
Molecular Function: potassium ion binding; protein binding; magnesium ion binding; ADP binding; pyruvate kinase activity; ATP binding
Biological Process: pyruvate biosynthetic process; response to gravity; organ regeneration; glycolysis; programmed cell death; glucose metabolic process; skeletal muscle regeneration; liver development; response to insulin stimulus; response to organic substance; ATP biosynthetic process; response to hypoxia; phosphorylation; response to nutrient; response to muscle inactivity
Research Articles on PKM
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Product Notes
The PKM pkm (Catalog #AAA230231) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PYRUVATE KINASE can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the PKM pkm for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PYRUVATE KINASE, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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