Rabbit IL27RA Polyclonal Antibody | anti-IL27RA antibody

IL27RA Polyclonal Antibody

Cat. Num. AAA2528129

• Gene Names: IL27RA; CRL1; TCCR; WSX1; IL27R; IL-27RA; zcytor1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: IL27RA; Polyclonal Antibody; IL27RA Polyclonal Antibody; CRL1; TCCR; WSX1; IL27R; IL-27RA; zcytor1; anti-IL27RA antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.5mg/mL (varies by lot)
• Sequence Length: 636

• Applicable Applications for anti-IL27RA antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:200-1:1000; IHC: 1:50-1:200
• Immunogen: Recombinant protein of human IL27RA
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of Mouse thymus and heart tissue using IL27RA Polyclonal Antibody at dilution of 1:400)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer using IL27RA Polyclonal Antibody at dilution of 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain using IL27RA Polyclonal Antibody at dilution of 1:40)

Related Product Information for anti-IL27RA antibody

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.

NCBI and Uniprot Product Information

• NCBI GI #: 4759328
• NCBI GeneID: 9466
• NCBI Accession #: NP_004834.1
• NCBI GenBank Nucleotide #: NM_004843.3
• Molecular Weight: 69,474 Da
• NCBI Official Full Name: interleukin-27 receptor subunit alpha
• NCBI Official Synonym Full Names: interleukin 27 receptor, alpha
• NCBI Official Symbol: IL27RA
• NCBI Official Synonym Symbols: CRL1; TCCR; WSX1; IL27R; IL-27RA; zcytor1
• NCBI Protein Information: interleukin-27 receptor subunit alpha; IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; T-cell cytokine receptor type 1; class I cytokine receptor; cytokine receptor WSX-1; cytokine receptor-like 1; type I T-cell cytokine receptor
• UniProt Protein Name: Interleukin-27 receptor subunit alpha
• Protein Family: Interleukin-27 receptor
• UniProt Gene Name: IL27RA
• UniProt Synonym Gene Names: CRL1; TCCR; WSX1; IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; TCCR
• UniProt Entry Name: I27RA_HUMAN

NCBI Description

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]

Uniprot Description

IL27RA: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms. Belongs to the type I cytokine receptor family. Type 2 subfamily.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: integral to plasma membrane

Molecular Function: interleukin-27 receptor activity; transmembrane receptor activity

Biological Process: defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; positive regulation of T-helper 1 type immune response; negative regulation of T-helper 2 type immune response; immune response; regulation of isotype switching to IgG isotypes