Western Blot (WB)
(Western blot analysis of A) Jurkat and B) K562 cell lysates (35ug protein in RIPA buffer) probed with DPF2 antibody (1ug/ml,MBS226145) and detected by chemiluminescence.)
Goat anti-Human DPF2 Polyclonal Antibody | anti-DPF2 antibody
Goat anti DPF2
0.02% Sodium Azide
0.5% Bovine Serum Albumin
Purified IgG - liquid
WB: 1ug/ml to 3ug/ml
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Western Blot (WB)
(Western blot analysis of A) Jurkat and B) K562 cell lysates (35ug protein in RIPA buffer) probed with DPF2 antibody (1ug/ml,MBS226145) and detected by chemiluminescence.)
Western Blot (WB)
(Western blot analysis of A) Jurkat and B) K562 cell lysates (35ug protein in RIPA buffer) probed with DPF2 antibody (1ug/ml,MBS226145) and detected by chemiluminescence.)
DPF2 is a plant homeodomain (PHD) finger protein with roles in apoptosis, noncanonical NF-kappaB signaling and oncogenesis (Liu et al. 2015). It acts as an adaptor protein, linking RelB/p52 with the SWI/SNF chromatin-remodeling complex (Shin et al. 2017). In human tissues, DPF2 is ubiquitously expressed but was discovered as being required for apoptosis in myeloid cells. Furthermore, this protein appears to play a role in inhibiting the differentiation of myeloid cells. DPF2 is associated with multiple human cancers including cervical cancer and acute myelogenous leukemia (AML) (Huber et al. 2017). DPF2 also appears to play a role in influenza infection, with knockdown of DPF2 leading to decreased infectivity of the virus (Shin et al. 2017).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]
Uniprot Description
requiem: May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells. Belongs to the requiem/DPF family.
Protein type: Apoptosis; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: nucleoplasm; centrosome; intracellular membrane-bound organelle; cytoplasm; nuclear chromatin
Molecular Function: zinc ion binding
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis
Research Articles on DPF2
Similar Products
Product Notes
The DPF2 dpf2 (Catalog #AAA226145) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti DPF2 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DPF2 can be used in a range of immunoassay formats including, but not limited to, Immunohistology-Paraffin (P), Western Blot (WB). P: 5ug/ml WB: 1ug/ml to 3ug/ml. Researchers should empirically determine the suitability of the DPF2 dpf2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DPF2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
