Mouse RPS6KB2 Monoclonal Antibody | anti-RPS6KB2 antibody
Mouse Anti RPS6KB2
Summary: Mouse anti Human RPS6KB2 antibody recognizes ribosomal protein S6 kinase beta-2, also known as P70 S6 kinase beta, 70 kDa ribosomal protein S6 kinase 2, P70S6K2, S6 kinase-related kinase, S6K-beta, S6K-beta-2, p70 S6K-beta, p70 ribosomal S6 kinase beta, p70-S6K 2, serine/threonine-protein kinase 14 beta and serine/threonine-protein kinase 14B.
The RPS6KB2 gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation (provided by RefSeq, Jul 2008).
Mouse anti Human RPS6KB2 antibody detects a band of 70 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
Uniprot Description
P70S6KB: an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported.
Protein type: Protein kinase, AGC; EC 2.7.11.1; Translation; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; RSK family; p70 subfamily
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: protein serine/threonine kinase activity; ribosomal protein S6 kinase activity; peptide binding; ATP binding; protein kinase activity
Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of translational initiation; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; translation; nerve growth factor receptor signaling pathway; protein kinase B signaling cascade; innate immune response; signal transduction; protein amino acid phosphorylation