Western Blot (WB)
(Western blot analysis of Jurkat cell lysate (lane 1), mouse intestine tissue lysate (lane 2) and rat kidney tissue lysate (lane 3) probed with Rabbit anti histone deacetylase 2 antibody)
Rabbit anti-Human DEACETYLASE 2 Polyclonal Antibody | anti-HDAC2 antibody
RABBIT ANTI HISTONE DEACETYLASE 2
Western Blot: 0.5; 4.0 ug/ml
Shelf Life: 12 months from date of despatch
Western Blot (WB)
(Western blot analysis of Jurkat cell lysate (lane 1), mouse intestine tissue lysate (lane 2) and rat kidney tissue lysate (lane 3) probed with Rabbit anti histone deacetylase 2 antibody)
Western Blot (WB)
(Western blot analysis of Jurkat cell lysate (lane 1), mouse intestine tissue lysate (lane 2) and rat kidney tissue lysate (lane 3) probed with Rabbit anti histone deacetylase 2 antibody)
NCBI and Uniprot Product Information
NCBI Description
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Uniprot Description
HDAC2: a transcriptional regulator of the histone deacetylase family, subfamily 1. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays a role in epigenetic repression and transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Protein type: EC 3.5.1.98; Nuclear receptor co-regulator; Deacetylase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: cytoplasm; ESC/E(Z) complex; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; protein complex; Sin3 complex
Molecular Function: chromatin binding; deacetylase activity; enzyme binding; heat shock protein binding; histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K14 specific); NF-kappaB binding; nucleosomal DNA binding; protein binding; protein deacetylase activity; sequence-specific DNA binding; transcription factor binding
Biological Process: ATP-dependent chromatin remodeling; behavioral response to ethanol; blood coagulation; chromatin remodeling; circadian regulation of gene expression; dendrite development; embryonic digit morphogenesis; epidermal cell differentiation; establishment and/or maintenance of chromatin architecture; gene expression; histone deacetylation; maintenance of chromatin silencing; negative regulation of apoptosis; negative regulation of cell cycle; negative regulation of DNA binding; negative regulation of gene expression, epigenetic; negative regulation of MHC class II biosynthetic process; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; odontogenesis of dentine-containing teeth; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of interleukin-1 production; positive regulation of oligodendrocyte differentiation; positive regulation of proteolysis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of gene expression, epigenetic; response to amphetamine; response to caffeine; response to cocaine; response to drug; response to hyperoxia; response to lipopolysaccharide; response to nicotine; transcription, DNA-dependent
Research Articles on HDAC2
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Product Notes
The HDAC2 hdac2 (Catalog #AAA224918) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RABBIT ANTI HISTONE DEACETYLASE 2 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DEACETYLASE 2 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Western Blot (WB). Immunocytochemistry: 10; 20 ug/ml Western Blot: 0.5; 4.0 ug/ml. Researchers should empirically determine the suitability of the HDAC2 hdac2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DEACETYLASE 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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