Testing Data #1
(Human peripheral blood lymphocytes stained with Mouse anti Human Siglec-7: Endotoxin Low (MBS224600))
Mouse SIGLEC-7 Monoclonal Antibody | anti-SIGLEC-7 antibody
MOUSE ANTI HUMAN SIGLEC-7
Purified IgG - liquid
Western Blot: This item detects a band of approximately 65kDa using Siglec-7 transfected CHO cells see Nicoll, G. et al. for details.
Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/200
Preparation
Fusion Partners
Shelf Life: 18 months from date of despatch.
Testing Data #1
(Human peripheral blood lymphocytes stained with Mouse anti Human Siglec-7: Endotoxin Low (MBS224600))
Testing Data #1
(Human peripheral blood lymphocytes stained with Mouse anti Human Siglec-7: Endotoxin Low (MBS224600))
Testing Data #2
(Human peripheral blood lymphocytes stained with Mouse anti Human Siglec-7: FITC (MBS224698))
Testing Data #2
(Human peripheral blood lymphocytes stained with Mouse anti Human Siglec-7: FITC (MBS224698))
Testing Data #3
(Human peripheral blood lymphocytes stained with Mouse anti Human Siglec-7: RPE)
Testing Data #3
(Human peripheral blood lymphocytes stained with Mouse anti Human Siglec-7: RPE)
NCBI and Uniprot Product Information
Uniprot Description
SIGLEC7: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: integral to plasma membrane
Molecular Function: receptor activity; carbohydrate binding
Biological Process: cell adhesion
Research Articles on SIGLEC-7
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Product Notes
The SIGLEC-7 siglec7 (Catalog #AAA224402) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SIGLEC-7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Flow cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB). Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells. Western Blot: This item detects a band of approximately 65kDa using Siglec-7 transfected CHO cells see Nicoll, G. et al. for details. Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/200. Researchers should empirically determine the suitability of the SIGLEC-7 siglec7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIGLEC-7, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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