Mouse CD39 Monoclonal Antibody | anti-CD39 antibody

MOUSE ANTI HUMAN CD39

Cat. Num. AAA219870

• Gene Names: ENTPD1; CD39; SPG64; ATPDase; NTPDase-1
• Applications: Flow Cytometry, Functional Assay, Immunofluorescence
• Synonyms: CD39; Monoclonal Antibody; MOUSE ANTI HUMAN CD39; anti-CD39 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: A1
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1.0 mg/ml (varies by lot)
• Sequence Length: 517

• Applicable Applications for anti-CD39 antibody: Flow cytometry (FC/FACS), Immunofluorescence (IF)
• Application Notes: Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells
• Perservative Stabilisers: 0.09% Sodium Azide; Preparation
• Buffer Solution: Phosphate buffered saline
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch

Testing Data

(Staining of human peripheral blood lymphocytes with Mouse anti Human CD39 followed by Rabbit F(ab')2 anti Mouse IgG:FITC (MBS235160))

Testing Data

(Staining of human peripheral blood lymphocytes with Mouse anti Human CD39:FITC (MBS210642))

Related Product Information for anti-CD39 antibody

Mouse anti human CD39, clone A1 recognizes the human CD39 cell surface antigen, a ~70-100kDa molecule expressed on peripheral blood B cells, monocytes and T lymphocytes, and weakly by granulocytes. CD39 has intrinsic ecto-ATPase activity (Wang et al. 1996), and expression can be induced on T cells and increased on B cells, as a late activation antigen (Maliszewski et al. 1994). Mouse anti human CD39, clone A1 has been shown to block MHC independent target cell recognition by hapten-specific CTL (Scholzen et al. 2009).

NCBI and Uniprot Product Information

• NCBI GI #: 147905700
• NCBI GeneID: 953
• NCBI Accession #: NP_001091645.1
• NCBI GenBank Nucleotide #: NM_001098175.1
• UniProt Accession #: P49961; Q5T561; Q5T562; Q86VV3; Q9UQQ9; Q9Y3Q9; A9Z1X8; B4DWB9; B4E1X1; B7Z599; G3XAF6
• Molecular Weight: 59,325 Da
• NCBI Official Full Name: ectonucleoside triphosphate diphosphohydrolase 1 isoform 2
• NCBI Official Synonym Full Names: ectonucleoside triphosphate diphosphohydrolase 1
• NCBI Official Symbol: ENTPD1
• NCBI Official Synonym Symbols: CD39; SPG64; ATPDase; NTPDase-1
• NCBI Protein Information: ectonucleoside triphosphate diphosphohydrolase 1; CD39 antigen; NTPDase 1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ecto-ATPase 1; ecto-apyrase; lymphoid cell activation antigen
• UniProt Protein Name: Ectonucleoside triphosphate diphosphohydrolase 1
• UniProt Gene Name: ENTPD1
• UniProt Synonym Gene Names: CD39; NTPDase 1; Ecto-ATPDase 1; Ecto-ATPase 1
• UniProt Entry Name: ENTP1_HUMAN

NCBI Description

The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Uniprot Description

ENTPD1: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. Belongs to the GDA1/CD39 NTPase family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; Membrane protein, multi-pass; EC 3.6.1.5; Extracellular matrix; Membrane protein, integral; Nucleotide Metabolism - pyrimidine; Hydrolase

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: membrane; integral to plasma membrane; plasma membrane; basal lamina

Molecular Function: protein binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity; ATP binding

Biological Process: G-protein coupled receptor protein signaling pathway; platelet activation; purine ribonucleoside diphosphate catabolic process; blood coagulation; cell adhesion

Disease: Spastic Paraplegia 64, Autosomal Recessive