Oxysterol Binding Protein Like Protein 8 Recombinant Protein | OSBPL8 recombinant protein

Recombinant Oxysterol Binding Protein Like Protein 8 (OSBPL8)

Cat. Num. AAA2123544

• Gene Names: OSBPL8; ORP8; MST120; OSBP10; MSTP120
• Applications: SDS-Page, Western Blot
• Purity: >90%
• Synonyms: Oxysterol Binding Protein Like Protein 8; Recombinant Oxysterol Binding Protein Like Protein 8 (OSBPL8); ORP8; OSBP10; Oxysterol-Binding Protein-Related Protein 8; OSBPL8 recombinant protein

• Host: E Coli
• Purity/Purification: >90%
• Form/Format: Freeze-dried powder; PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Positions: Val148~Lys265
• Sequence Length: 886

• Applicable Applications for OSBPL8 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Prokaryotic expression
• Species: Human
• Tag: N-terminal His Tag
• Subcellular Location: Endoplasmic reticulum membrane, Nucleus membrane
• Isoelectric Point: 9.3
• Reconstitution: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for OSBPL8 recombinant protein

Metabolic pathway

NCBI and Uniprot Product Information

• NCBI GI #: 985567518
• NCBI GeneID: 114882
• NCBI Accession #: NP_001306582.1
• NCBI GenBank Nucleotide #: NP_001306582.1
• UniProt Accession #: Q9BZF1
• Molecular Weight: Predicted Molecular Mass: 17kDa; Accurate Molecular Mass: 15kDa
• NCBI Official Full Name: oxysterol-binding protein-related protein 8 isoform c
• NCBI Official Synonym Full Names: oxysterol binding protein like 8
• NCBI Official Symbol: OSBPL8
• NCBI Official Synonym Symbols: ORP8; MST120; OSBP10; MSTP120
• NCBI Protein Information: oxysterol-binding protein-related protein 8
• UniProt Protein Name: Oxysterol-binding protein-related protein 8
• Protein Family: Oxysterol-binding protein-related protein
• UniProt Gene Name: OSBPL8
• UniProt Synonym Gene Names: ORP-8; OSBP-related protein 8

NCBI Description

This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Description

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267).