Rabbit anti-Human Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Polyclonal Antibody | anti-EMMPRIN antibody

Biotin-Linked Polyclonal Antibody to Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)

Cat. Num. AAA2093439

• Gene Names: BSG; OK; 5F7; TCSF; CD147; EMMPRIN
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Synonyms: Extracellular Matrix Metalloproteinase Inducer (EMMPRIN); Polyclonal Antibody; Biotin-Linked Polyclonal Antibody to Extracellular Matrix Metalloproteinase Inducer (EMMPRIN); CD147; BSG; 5F7; M6; OK; TCSF; Basigin(Ok Blood Group); Collagenase stimulatory factor; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; anti-EMMPRIN antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Concentration: 500ug/ml (varies by lot)
• Sequence Length: 269

• Applicable Applications for anti-EMMPRIN antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Conjugation: Biotin
• Cross Reactivity: Human
• Immunogen: EMMPRIN (Val79~Gln280)

NCBI and Uniprot Product Information

• NCBI GI #: 1220307
• NCBI GeneID: 682
• Molecular Weight: 22,764 Da
• NCBI Official Full Name: extracellular matrix metalloproteinase inducer
• NCBI Official Synonym Full Names: basigin (Ok blood group)
• NCBI Official Symbol: BSG
• NCBI Official Synonym Symbols: OK; 5F7; TCSF; CD147; EMMPRIN
• NCBI Protein Information: basigin
• UniProt Protein Name: Basigin
• UniProt Gene Name: BSG
• UniProt Synonym Gene Names: EMMPRIN; TCSF

NCBI Description

The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

BSG: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: acrosomal membrane; focal adhesion; Golgi membrane; integral component of plasma membrane; intracellular membrane-bound organelle; melanosome; membrane; membrane raft; mitochondrion; plasma membrane; sarcolemma

Molecular Function: cadherin binding; mannose binding; monocarboxylic acid transmembrane transporter activity; protein binding

Biological Process: cell surface receptor signaling pathway; decidualization; embryo implantation; extracellular matrix disassembly; extracellular matrix organization; leukocyte migration; monocarboxylic acid transport; odontogenesis of dentine-containing teeth; pyruvate metabolic process; response to cAMP; response to mercury ion; response to peptide hormone

Disease: Blood Group--ok