Rabbit anti-Mouse Complement Receptor 2 (CR2) Polyclonal Antibody | anti-CR2 antibody

Biotin-Linked Polyclonal Antibody to Complement Receptor 2 (CR2)

Cat. Num. AAA2092429

• Gene Names: CR2; CR; C3DR; CD21; CVID7; SLEB9
• Reactivity: Mouse
• Applications: Western Blot, Immunohistochemistry
• Synonyms: Complement Receptor 2 (CR2); Polyclonal Antibody; Biotin-Linked Polyclonal Antibody to Complement Receptor 2 (CR2); CD21; C3DR; Complement Component(3d/Epstein Barr Virus)Receptor 2; Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; anti-CR2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Concentration: 500ug/ml (varies by lot)
• Sequence Length: 1092

• Applicable Applications for anti-CR2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Conjugation: Biotin
• Cross Reactivity: Mouse
• Immunogen: CR2 (Cys463~Asp665)

NCBI and Uniprot Product Information

• NCBI GI #: 54792123
• NCBI GeneID: 1380
• NCBI Accession #: NP_001006659.1
• NCBI GenBank Nucleotide #: NM_001006658.2
• UniProt Accession #: P20023; Q13866; Q14212; Q53EL2; Q5BKT9; Q5SR46; Q5SR48; C9JHD2
• Molecular Weight: 118,279 Da
• NCBI Official Full Name: complement receptor type 2 isoform 1
• NCBI Official Synonym Full Names: complement C3d receptor 2
• NCBI Official Symbol: CR2
• NCBI Official Synonym Symbols: CR; C3DR; CD21; CVID7; SLEB9
• NCBI Protein Information: complement receptor type 2
• UniProt Protein Name: Complement receptor type 2
• Protein Family: Complement receptor
• UniProt Gene Name: CR2
• UniProt Synonym Gene Names: C3DR; Cr2; EBV receptor

NCBI Description

This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Uniprot Description

CR2: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7). A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Belongs to the receptors of complement activation (RCA) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: integral component of membrane; plasma membrane; receptor complex

Molecular Function: complement binding; complement receptor activity; DNA binding; protein binding; protein homodimerization activity; transmembrane receptor activity; viral receptor activity

Biological Process: B cell differentiation; B cell proliferation; complement activation, classical pathway; complement receptor mediated signaling pathway; entry of virus into host cell; immune response; innate immune response; regulation of complement activation

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 7; Systemic Lupus Erythematosus, Susceptibility To, 9