Western Blot (WB)
(Western blot analysis of anti-YARS2 Antibody (N-term) in K562 cell line lysates (35ug/lane). YARS(arrow) was detected using the purified Pab.)
Rabbit anti-Human YARS2 Polyclonal Antibody | anti-YARS2 antibody
YARS2 Antibody (N-term)
Western Blot (WB)
(Western blot analysis of anti-YARS2 Antibody (N-term) in K562 cell line lysates (35ug/lane). YARS(arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of anti-YARS2 Antibody (N-term) in K562 cell line lysates (35ug/lane). YARS(arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with YARS2 antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with YARS2 antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Bonnefond,L., RNA 11 (5), 558-562 (2005)
Bonnefond,L., Biochemistry 44 (12), 4805-4816 (2005)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]
Uniprot Description
YARS2: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS2 are the cause of myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). MLASA2 is a rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest sideroblastic anemia, progressive lethargy, muscle weakness, and exercise intolerance associated with persistent lactic acidemia. Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein type: Ligase; Translation; RNA-binding; Mitochondrial; EC 6.1.1.1
Chromosomal Location of Human Ortholog: 12p11.21
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: protein homodimerization activity; tyrosine-tRNA ligase activity; ATP binding; tRNA binding
Biological Process: tRNA aminoacylation for protein translation; translation; gene expression; tRNA aminoacylation
Disease: Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Research Articles on YARS2
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Product Notes
The YARS2 yars2 (Catalog #AAA9204249) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 43-71. The YARS2 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's YARS2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the YARS2 yars2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "YARS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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