Mouse Parathyroid Hormone Related Protein (PTHrP) ELISA Kit | PTHrP elisa kit
Mouse Parathyroid Hormone Related Protein (PTHrP) Mini Samples ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the parathyroid family of hormones that possesses distinct paracrine and intracrine signaling roles such as regulation of circulating calcium, transplacental calcium transport, osteoclast inhibition, renal bicarbonate excretion and regulation of apoptosis. The encoded protein undergoes proteolytic processing to generate multiple active peptides with distinct signaling functions. The homozygous deletion of this gene leads to death shortly after birth with a chondrodystrophic phenotype characterized by premature chondrocyte differentiation and accelerated bone formation. [provided by RefSeq, Jul 2015]
Uniprot Description
PTHrP: a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Three alternatively spliced isoforms have been described.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6 G3|6 78.19 cM
Cellular Component: cytoplasm; extracellular space; Golgi apparatus; intracellular; nucleoplasm
Molecular Function: hormone activity; peptide hormone receptor binding
Biological Process: alveolus development; bone mineralization; endochondral ossification; endoderm development; epithelial cell differentiation; G-protein signaling, adenylate cyclase activating pathway; negative regulation of chondrocyte differentiation; negative regulation of transcription factor activity; osteoblast development; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; protein processing; regulation of gene expression; skeletal development; surfactant homeostasis
Research Articles on PTHrP
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Product Notes
The Mouse PTHrP pthlh (Catalog #AAA2087613) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2087613 ELISA Kit recognizes Mouse PTHrP. It is sometimes possible for the material contained within the vial of "Parathyroid Hormone Related Protein (PTHrP), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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