Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit | AGER elisa kit
Rat Advanced Glycosylation End Product Specific Receptor (AGER) Mini Samples ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
cell surface receptor for various molecules, including the amyloidogenic form of serum amyloid A [RGD, Feb 2006]
Uniprot Description
RAGE: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Interacts with S100B, S100A1 and APP. Interacts with S100A12. Endothelial cells. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 20p12
Cellular Component: axon; basal plasma membrane; cell soma; cell surface; cytoplasm; cytosol; extracellular region; extracellular space; plasma membrane
Molecular Function: advanced glycation end-product receptor activity; heparin binding; identical protein binding; protein binding
Biological Process: activation of NF-kappaB transcription factor; astrocyte development; brain development; calcium ion homeostasis; glycoprotein metabolic process; induction of positive chemotaxis; inflammatory response; JAK-STAT cascade; lung development; negative regulation of cell adhesion; negative regulation of collagen biosynthetic process; negative regulation of endothelial cell proliferation; negative regulation of interleukin-10 production; negative regulation of osteoblast proliferation; negative regulation of protein amino acid phosphorylation; neurite development; positive regulation of activated T cell proliferation; positive regulation of apoptosis; positive regulation of autophagy; positive regulation of cell migration; positive regulation of fibroblast proliferation; positive regulation of inflammatory response; positive regulation of interleukin-12 production; positive regulation of JNK activity; positive regulation of neuron apoptosis; positive regulation of phagocytosis, engulfment; positive regulation of protein amino acid phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; regulation of DNA binding; regulation of inflammatory response; regulation of T cell mediated cytotoxicity; response to activity; response to fructose stimulus; response to genistein; response to hyperoxia; response to hypoxia; response to methylglyoxal; response to vitamin A
Research Articles on AGER
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Product Notes
The Rat AGER ager (Catalog #AAA2087520) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2087520 ELISA Kit recognizes Rat AGER. It is sometimes possible for the material contained within the vial of "Advanced Glycosylation End Product Specific Receptor (AGER), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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