Rabbit anti-Mouse Toll Like Receptor Adaptor Molecule 1 (TICAM1) Polyclonal Antibody | anti-TICAM1 antibody

Cy3-Linked Polyclonal Antibody to Toll Like Receptor Adaptor Molecule 1 (TICAM1)

Cat. Num. AAA2079114

• Gene Names: TICAM1; TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1
• Reactivity: Mouse
• Applications: Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA
• Synonyms: Toll Like Receptor Adaptor Molecule 1 (TICAM1); Polyclonal Antibody; Cy3-Linked Polyclonal Antibody to Toll Like Receptor Adaptor Molecule 1 (TICAM1); TRIF; PRVTIRB; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; Proline-rich; vinculin and TIR domain-containing protein B; anti-TICAM1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Concentration: >=100ug/ml (varies by lot)

• Applicable Applications for anti-TICAM1 antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
• Immunogen: TICAM1 (Ser263~Val526)
• Conjugation: Cy3
• Cross Reactivity: Mouse
• Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2026370

NCBI and Uniprot Product Information

• NCBI GI #: 223460864
• NCBI GeneID: 148022
• Molecular Weight: 76,422 Da
• NCBI Official Full Name: Toll-like receptor adaptor molecule 1
• NCBI Official Synonym Full Names: toll like receptor adaptor molecule 1
• NCBI Official Symbol: TICAM1
• NCBI Official Synonym Symbols: TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1
• NCBI Protein Information: TIR domain-containing adapter molecule 1
• UniProt Protein Name: TIR domain-containing adapter molecule 1
• Protein Family: TIR domain-containing adapter molecule
• UniProt Gene Name: TICAM1
• UniProt Synonym Gene Names: PRVTIRB; TRIF; TICAM-1; MyD88-3; TIR domain-containing adapter protein inducing IFN-beta

NCBI Description

This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]

Uniprot Description

TICAM1: an adaptor protein involved in innate immunity against invading pathogens. Associates with TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Interacts with the TIR domain of TLR3. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3. Interacts with TRAFD1.

Protein type: Adaptor/scaffold; Apoptosis

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytosol; endosome membrane

Molecular Function: protein binding; protein kinase binding; signal transducer activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; positive regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to exogenous dsRNA

Disease: Herpes Simplex Encephalitis, Susceptibility To, 4