SDS-Page
KLHDC8B recombinant protein
KLHDC8B, 1-354aa, Human, His tag, E Coli (Denatured)
Gene Names
KLHDC8B; CHL
Applications
SDS-Page
Purity
> 85% by SDS-PAGE
Synonyms
KLHDC8B; 1-354aa; Human; His tag; E Coli (Denatured); Kelch domain-containing protein 8B; FP17659; Kelch domain containing protein 8B; MGC35097; KLHDC8B recombinant protein
Host
E Coli
Purity/Purification
> 85% by SDS-PAGE
Form/Format
Liquid. In phosphate buffer saline (pH 7.4) containing 10% glycerol
Concentration
0.5 mg/ml (determined by Bradford assay) (varies by lot)
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMSAGGGR AFAWQVFPPM PTCRVYGTVA HQDGHLLVLG GCGRAGLPLD TAETLDMASH TWLALAPLPT ARAGAAAVVL GKQVLVVGGV DEVQSPVAAV EAFLMDEGRW ERRATLPQAA MGVATVERDG MVYALGGMGP DTAPQAQVRV YEPRRDCWLS LPSMPTPCYG ASTFLHGNKI YVLGGRQGKL PVTAFEAFDL EARTWTRHPS LPSRRAFAGC AMAEGSVFSL GGLQQPGPHN FYSRPHFVNT VEMFDLEHGS WTKLPRSLRM RDKRADFVVG SLGGHIVAIG GLGNQPCPLG SVESFSLARR RWEALPAMPT ARCSCSSLQA GPRLFVIGGV AQGPSQAVEA LCLRDGV
Sequence Length
354
Applicable Applications for KLHDC8B recombinant protein
SDS-PAGE
Antigen Species
Human
Tag Information
His-tag
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
SDS-Page
SDS-Page
Related Product Information for KLHDC8B recombinant protein
KLHDC8B forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in KLHDC8B have been associated with Hodgkin lymphoma. Recombinant human KLHDC8B protein, fused to His-tag at N-terminus, was expressed in E Coli.
References
Wan D., et al (2004). Proc. Natl. Acad. Sci. u.S.A. 101:15724-15729; Salipante S.J., et al (2009). Proc. Natl. Acad. Sci. u.S.A. 106:14920-14925;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
40.1 kDa (377aa)
NCBI Official Full Name
kelch domain-containing protein 8B
NCBI Official Synonym Full Names
kelch domain containing 8B
NCBI Official Symbol
KLHDC8B
NCBI Official Synonym Symbols
CHL
NCBI Protein Information
kelch domain-containing protein 8B
UniProt Protein Name
Kelch domain-containing protein 8B
Protein Family
UniProt Gene Name
KLHDC8B
NCBI Description
This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]
Uniprot Description
Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010).
Research Articles on KLHDC8B
Similar Products
Product Notes
The KLHDC8B klhdc8b (Catalog #AAA205811) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The tag for this protein is His-tag. AAA Biotech's KLHDC8B can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE. Researchers should empirically determine the suitability of the KLHDC8B klhdc8b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MGSSHHHHHH SSGLVPRGSH MGSMSAGGGR AFAWQVFPPM PTCRVYGTVA HQDGHLLVLG GCGRAGLPLD TAETLDMASH TWLALAPLPT ARAGAAAVVL GKQVLVVGGV DEVQSPVAAV EAFLMDEGRW ERRATLPQAA MGVATVERDG MVYALGGMGP DTAPQAQVRV YEPRRDCWLS LPSMPTPCYG ASTFLHGNKI YVLGGRQGKL PVTAFEAFDL EARTWTRHPS LPSRRAFAGC AMAEGSVFSL GGLQQPGPHN FYSRPHFVNT VEMFDLEHGS WTKLPRSLRM RDKRADFVVG SLGGHIVAIG GLGNQPCPLG SVESFSLARR RWEALPAMPT ARCSCSSLQA GPRLFVIGGV AQGPSQAVEA LCLRDGV. It is sometimes possible for the material contained within the vial of "KLHDC8B, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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