TuLP1 recombinant protein

TuLP1, 290-542aa, Human, His tag, E Coli

Cat. Num. AAA204393

• Gene Names: TULP1; RP14; LCA15; TUBL1
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: TuLP1; 290-542aa; Human; His tag; E Coli; Tubby-related protein 1; LCA15; RP14; TuBL1; TuLP1 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 5mM DTT, 2mM EDTA
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSEPREFVL RPAPQGRTVR CRLTRDKKGM DRGMYPSYFL HLDTEKKVFL LAGRKRKRSK TANYLISIDP TNLSRGGENF IGKLRSNLLG NRFTVFDNGQ NPQRGYSTNV ASLRQELAAV IYETNVLGFR GPRRMTVIIP GMSAENERVP IRPRNASDGL LVRWQNKTLE SLIELHNKPP VWNDDSGSYT LNFQGRVTQA SVKNFQIVHA DDPDYIVLQF GRVAEDAFTL DYRYPLCALQ AFAIALSSFD GKLACE
• Sequence Length: 542

• Applicable Applications for TuLP1 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for TuLP1 recombinant protein

Tubby-related protein 1, also known as TuLP1, is a member of the TuLP family of four proteins (TuB and TuLP1, -2, and -3), characterized structurally by the highly conserved C-terminal half of the protein. In the retina, TuLP1 is found exclusively in photoreceptor cells, localizing primarily in the inner segments and connecting cilium and to a lesser extent in the perinuclear cytoplasm and synaptic termini. Recombinant human TuLP1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for TuLP1 recombinant protein

Neuroscience

References

Xi Q., et al. (2005) Invest. Ophthalmol. Vis. Sci. 46:4754-4761; Caberoy N.B., et al. (2010) Exp. Cell Res. 316:245-257

NCBI and Uniprot Product Information

• NCBI GI #: 157266334
• NCBI GeneID: 7287
• NCBI Accession #: NP_003313
• NCBI GenBank Nucleotide #: NM_003322.5
• UniProt Accession #: O00294; O43536; Q5TGM5; Q8N571
• Molecular Weight: 31.1 kDa (276aa), confirmed by MALDI-TOF
• NCBI Official Full Name: tubby-related protein 1 isoform 1
• NCBI Official Synonym Full Names: tubby like protein 1
• NCBI Official Symbol: TULP1
• NCBI Official Synonym Symbols: RP14; LCA15; TUBL1
• NCBI Protein Information: tubby-related protein 1
• UniProt Protein Name: Tubby-related protein 1
• Protein Family: Tubby-related protein
• UniProt Gene Name: TULP1
• UniProt Synonym Gene Names: TUBL1

NCBI Description

This gene encodes a member of the tubby-like gene family (TULPs). Members of this family have been identified in plants, vertebrates, and invertebrates. TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. The protein encoded by this gene is thought to play a role in the physiology of photoreceptors. Mutations in this gene are associated with recessive juvenile retinitis pigmentosa and Leber congenital amaurosis-15. [provided by RefSeq, Nov 2016]

Uniprot Description

Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.