RAC2 recombinant protein

RAC2, 1-192aa, Human, GST tag, E Coli

Cat. Num. AAA203164

• Gene Names: RAC2; Gx; EN-7; HSPC022; p21-Rac2
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: RAC2; 1-192aa; Human; GST tag; E Coli; Ras-related C3 botulinum toxin substrate 2; HSPC022; ras-related C3 botulinum toxin substrate 2; EN-7; Gx; Ras-related C3 botulinum toxin substrate 2 EN 7; EN7; HSPC 022; p21 Rac 2; p21 Rac2; p21Rac2; RAC 2; Ras related C3 botulinum toxin substrate 2; Ras related C3 botulinum toxin substrate 3; Rho family small GTP binding protein Rac 2; Rho family small GTP binding protein Rac2; Small G protein.; RAC2 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid in phosphate buffered saline pH 7.4
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD LVPRGSHMQA IKCVVVGDGA VGKTCLLISY TTNAFPGEYI PTVFDNYSAN VMVDSKPVNL GLWDTAGQED YDRLRPLSYP QTDVFLICFS LVSPASYENV RAKWFPEVRH HCPSTPIILV GTKLDLRDDK DTIEKLKEKK LAPITYPQGL ALAKEIDSVK YLECSALTQR GLKTVFDEAI RAVLCPQPTR QQKRACSLL
• Sequence Length: 192

• Applicable Applications for RAC2 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: GST tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for RAC2 recombinant protein

Rac2 is a small signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. Rac proteins play important roles in multiple cellular events, including actin cytoskeletal organization, cell proliferation and survival, cell cycle progression, and gene transcription regulation. Recombinant GST tagged RAC2 was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for RAC2 recombinant protein

Signal Transduction

References

Yi Gu., et al. (2002). Mol Cell Biol. 22 (21):7645-57.; Tarricone C., et al. (2001). Nature. 411 (6834):215-9.;

NCBI and Uniprot Product Information

• NCBI GI #: 4506381
• NCBI GeneID: 5880
• NCBI Accession #: NP_002863
• NCBI GenBank Nucleotide #: NM_002872.4
• UniProt Accession #: P15153; Q9UDJ4
• Molecular Weight: 47 kDa (419 aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: ras-related C3 botulinum toxin substrate 2
• NCBI Official Synonym Full Names: Rac family small GTPase 2
• NCBI Official Symbol: RAC2
• NCBI Official Synonym Symbols: Gx; EN-7; HSPC022; p21-Rac2
• NCBI Protein Information: ras-related C3 botulinum toxin substrate 2
• UniProt Protein Name: Ras-related C3 botulinum toxin substrate 2
• Protein Family: Ras-related protein
• UniProt Gene Name: RAC2

NCBI Description

This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

Uniprot Description

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.