Western Blot (WB)
(Western Blot: Sample: Rat Liver Tissue.)
Rabbit anti-Mouse Epidermal Growth Factor Receptor 2 Polyclonal Antibody | anti-EGFR2 antibody
Polyclonal Antibody to Epidermal Growth Factor Receptor 2 (EGFR2)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- FLPE SFDGNPSSGV APLKPEHLQV FETLEEITGY LYISAWPESF QDLSVFQNLR VIRGRILHDG AYSLTLQGLG IHSLGLRSLR ELGSGLALIH RNTHLCFVNT VPWDQLFRNP HQALLHSGNR PEEACGLEGL VCNSLCARGH CWGPGPTQCV NCSQFLRGQE CVEECRVWKG LPREYVRGKH
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Rat Liver Tissue.)
Western Blot (WB)
(Western Blot: Sample: Rat Liver Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Kidney tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Kidney tissue))
NCBI and Uniprot Product Information
Uniprot Description
HER2: a proto-oncogenic receptor tyrosine kinase of the EGFR family. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. Not activated by EGF, TGF- alpha and amphiregulin. Amplified in breast cancer. Overexpression induces constitutive activity, and the gene is amplified or overexpressed in up to 30% of breast cancers, correlating with poor survival. The antibody Herceptin is approved for treatment of metastatic breast cancer with HER2 amplification/overexpression. Somatic mutations seen in 4% of lung cancers and also in breast, gastric, ovarian cancer and glioblastoma. One SNP shows predisposition to breast and gastric cancer. Inhibitors: Herceptin, lapatinib, PKI-166, EKB-569, CI-1033.
Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 11 61.75 cM|11 D
Cellular Component: apical plasma membrane; basal plasma membrane; basolateral plasma membrane; cytoplasm; cytoplasmic vesicle; cytosol; endosome membrane; integral component of membrane; lateral loop; membrane; membrane raft; microvillus; myelin sheath; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; receptor complex
Molecular Function: ATP binding; growth factor binding; Hsp90 protein binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; signal transducer, downstream of receptor, with protein tyrosine kinase activity; transferase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity; ubiquitin protein ligase binding
Biological Process: cell surface receptor signaling pathway; cellular response to epidermal growth factor stimulus; cellular response to growth factor stimulus; glial cell differentiation; heart development; motor axon guidance; myelination; negative regulation of apoptosis; negative regulation of immature T cell proliferation in the thymus; nervous system development; neuromuscular junction development; oligodendrocyte differentiation; peripheral nervous system development; phosphoinositide 3-kinase cascade; phosphorylation; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of Ras protein signal transduction; positive regulation of transcription from RNA polymerase I promoter; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein amino acid phosphorylation; protein autophosphorylation; regulation of ERK1 and ERK2 cascade; regulation of microtubule-based process; regulation of transcription, DNA-templated; response to axon injury; signal transduction; sympathetic nervous system development; transcription, DNA-dependent; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing
Research Articles on EGFR2
Similar Products
Product Notes
The EGFR2 erbb2 (Catalog #AAA2027544) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Epidermal Growth Factor Receptor 2 (EGFR2) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Epidermal Growth Factor Receptor 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-2ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the EGFR2 erbb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- FLPE SFDGNPSSGV APLKPEHLQV FETLEEITGY LYISAWPESF QDLSVFQNLR VIRGRILHDG AYSLTLQGLG IHSLGLRSLR ELGSGLALIH RNTHLCFVNT VPWDQLFRNP HQALLHSGNR PEEACGLEGL VCNSLCARGH CWGPGPTQCV NCSQFLRGQE CVEECRVWKG LPREYVRGKH. It is sometimes possible for the material contained within the vial of "Epidermal Growth Factor Receptor 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
