Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Human Integrin Alpha 1 Polyclonal Antibody | anti-ITGa1 antibody
Polyclonal Antibody to Integrin Alpha 1 (ITGa1)
MHHHHHHSSG LVPRGSGMKE TAAAKFERQH MDSPDLGTDD DDKAMADIGS- GGFLAC GPLYAYRCGH LHYTTGICSD VSPTFQVVNS IAPVQECSTQ LDIVIVLDGS NSIYPWDSVT AFLNDLLERM DIGPKQTQVG IVQYGENVTH EFNLNKYSST EEVLVAAKKI VQRGGRQTMT ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNHRL KKVIQDCEDE NIQRFSIAIL GSYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT IVKTLGERIF ALEATA
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Description
ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: axon; axon terminus; cell surface; external side of plasma membrane; focal adhesion; integrin alpha2-beta1 complex; integrin complex; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: amyloid-beta binding; collagen binding; collagen binding involved in cell-matrix adhesion; collagen receptor activity; heparan sulfate proteoglycan binding; integrin binding; laminin binding; metal ion binding; protein binding; protein complex binding; protein heterodimerization activity; viral receptor activity
Biological Process: blood coagulation; cell adhesion; cell adhesion mediated by integrin; cell proliferation; cell-matrix adhesion; cell-substrate adhesion; cellular response to estradiol stimulus; collagen-activated signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; entry of virus into host cell; establishment of protein localization; extracellular matrix organization; female pregnancy; focal adhesion assembly; hepatocyte differentiation; hypotonic response; integrin-mediated signaling pathway; mammary gland development; mesodermal cell differentiation; organ morphogenesis; positive regulation of alkaline phosphatase activity; positive regulation of cell adhesion; positive regulation of cell projection organization; positive regulation of collagen binding; positive regulation of collagen biosynthetic process; positive regulation of DNA binding; positive regulation of epithelial cell migration; positive regulation of inflammatory response; positive regulation of leukocyte migration; positive regulation of phagocytosis, engulfment; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of translation; positive regulation of transmission of nerve impulse; response to amine; response to drug; response to hypoxia; response to L-ascorbic acid; response to muscle activity; response to parathyroid hormone; skin morphogenesis; substrate-bound cell migration
Disease: Bleeding Disorder, Platelet-type, 9
Research Articles on ITGa1
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Product Notes
The ITGa1 itga2 (Catalog #AAA2026047) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Integrin Alpha 1 (ITGa1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Integrin Alpha 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-2ug/ml Immunocytochemistry in formalin fixed cells: 5-20ug/ml Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml Immunohistochemistry in paraffin section: 5-20ug/ml Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the ITGa1 itga2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and S-tag and its sequence is listed below. MHHHHHHSSG LVPRGSGMKE TAAAKFERQH MDSPDLGTDD DDKAMADIGS - GGFLAC GPLYAYRCGH LHYTTGICSD VSPTFQVVNS IAPVQECSTQ LDIVIVLDGS NSIYPWDSVT AFLNDLLERM DIGPKQTQVG IVQYGENVTH EFNLNKYSST EEVLVAAKKI VQRGGRQTMT ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNHRL KKVIQDCEDE NIQRFSIAIL GSYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT IVKTLGERIF ALEATA. It is sometimes possible for the material contained within the vial of "Integrin Alpha 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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