DNAL1 cdna clone

DNAL1

Cat. Num. AAA200855

• Gene Names: DNAL1; LC1; CILD16; C14orf168
• Synonyms: DNAL1; C14orf168; CILD16; DNAL1 cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGGCGAAAGCAACAACAATCAAAGAAGCCTTAGCGAGATGGGAAGAGAAAACTGGCCAGAGGCCATCTGAAGCCAAAGAGATAAAACTTTATGCCCAGATTCCCCCTATAGAGAAGATGGATGCATCCTTGTCCATGCTTGCTAATTGCGAGAAGCTTTCACTGTCTACAAACTGCATTGAAAAAATTGCCAACCTGAATGGCTTAAAAAACTTGAGGATATTATCTTTAGGAAGAAACAACATAAAGAACTTAAATGGACTGGAGGCAGTAGGGGACACATTAGAAGAACTGTGGATCTCCTACAATTTTATTGAGAAGTTGAAAGGGATCCACATAATGAAGAAATTGAAGATTCTCTACATGTCTAATAACCTGGTAAAAGACTGGGCTGAGTTTGTGAAGCTGGCAGAACTGCCATGCCTCGAAGACCTGGTGTTTGTAGGCAATCCCTTGGAAGAGAAACATTCTGCTGAGAATAACTGGATTGAAGAAGCAACCAAGAGAGTGCCCAAACTGAAAAAGCTGGATGGTACTCCAGTAATTAAAGGGGATGAGGAAGAAGACAACTAA; ; Translation Sequence: MAKATTIKEA LARWEEKTGQ RPSEAKEIKL YAQIPPIEKM DASLSMLANC EKLSLSTNCI EKIANLNGLK NLRILSLGRN NIKNLNGLEA VGDTLEELWI SYNFIEKLKG IHIMKKLKIL YMSNNLVKDW AEFVKLAELP CLEDLVFVGN PLEEKHSAEN NWIEEATKRV PKLKKLDGTP VIKGDEEEDN
• Sequence Length: 190

• Species: Human
• Chromosome Location: 14q24.3
• OMIM Reference Number: 610062
• cDNA Size: 573bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted Nde I to Hind III. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for DNAL1 cdna clone

DNAL1 is an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. DNAL1 is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.

Product Categories/Family for DNAL1 cdna clone

Cytoskeleton

NCBI and Uniprot Product Information

• NCBI GI #: 164607156
• NCBI GeneID: 83544
• NCBI Accession #: NP_113615.2
• NCBI GenBank Nucleotide #: NM_031427.3
• UniProt Accession #: Q4LDG9
• NCBI Official Full Name: dynein light chain 1, axonemal isoform 1
• NCBI Official Synonym Full Names: dynein axonemal light chain 1
• NCBI Official Symbol: DNAL1
• NCBI Official Synonym Symbols: LC1; CILD16; C14orf168
• NCBI Protein Information: dynein light chain 1, axonemal
• UniProt Protein Name: Dynein light chain 1, axonemal
• Protein Family: Dynein
• UniProt Gene Name: DNAL1
• UniProt Synonym Gene Names: C14orf168
• UniProt Entry Name: DNAL1_HUMAN

NCBI Description

This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]

Uniprot Description

DNAL1: Defects in DNAL1 are the cause of primary ciliary dyskinesia type 16 (CILD16). A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Belongs to the dynein light chain LC1-type family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q24.3

Disease: Ciliary Dyskinesia, Primary, 16