HPGD cdna clone
HPGD
Translation Sequence: MHVNGKVALV TGAAQGIGRA FAEALLLKGA KVALVDWNLE AGVQCKAALD EQFEPQKTLF IQCDVADQQQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW EKTLQINLVS VISGTYLGLD YMSKQNGGEG GIIINMSSLA GLMPVAQQPV YCASKHGIVG FTRSAALAAN LMNSGVRLNA ICPGFVNTAI LESIEKEENM GQYIEYKDHI KDMIKYYGIL DPPLIANGLI TLIEDDALNG AIMKITTSKG IHFQDYDTTP FQAKTQ
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Description
HPGD: Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of hypertrophic osteoarthropathy, primary, autosomal recessive, type 1 (PHOAR1). A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. Defects in HPGD are the cause of cranioosteoarthropathy (COA). A form of osterarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. Defects in HPGD are a cause of isolated congenital nail clubbing (ICNC); also called clubbing of digits or hereditary acropachy. ICNC is a rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor; EC 1.1.1.141; Oxidoreductase
Chromosomal Location of Human Ortholog: 4q34-q35
Cellular Component: basolateral plasma membrane; cytosol
Molecular Function: protein homodimerization activity; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; catalytic activity; NAD binding; prostaglandin E receptor activity
Biological Process: ovulation; lipoxygenase pathway; transforming growth factor beta receptor signaling pathway; cyclooxygenase pathway; arachidonic acid metabolic process; female pregnancy; parturition; negative regulation of cell cycle; prostaglandin metabolic process
Disease: Digital Clubbing, Isolated Congenital; Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
Research Articles on HPGD
Similar Products
Product Notes
The HPGD hpgd (Catalog #AAA200652) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Nucleotide Sequence: ATGCACGTGA ACGGCAAAGT GGCGCTGGTG ACCGGCGCGG CTCAGGGCAT AGGCAGAGCC TTTGCAGAGG CGCTGCTGCT TAAGGGCGCC AAGGTAGCGC TGGTGGATTG GAATCTTGAA GCAGGTGTAC AGTGTAAAGC TGCCCTGGAT GAGCAGTTTG AACCTCAGAA GACTCTGTTC ATCCAGTGCG ATGTGGCTGA CCAGCAACAA CTGAGAGACA CTTTTAGAAA AGTTGTAGAC CACTTTGGAA GACTGGACAT TTTGGTCAAT AATGCTGGAG TGAATAATGA GAAAAACTGG GAAAAAACTC TGCAAATTAA TTTGGTTTCT GTTATCAGTG GAACCTATCT TGGTTTGGAT TACATGAGTA AGCAAAATGG AGGTGAAGGC GGCATCATTA TCAATATGTC ATCTTTAGCA GGACTCATGC CCGTTGCACA GCAGCCGGTT TATTGTGCTT CAAAGCATGG CATAGTTGGA TTCACACGCT CAGCAGCGTT GGCTGCTAAT CTTATGAACA GTGGTGTGAG ACTGAATGCC ATTTGTCCAG GCTTTGTTAA CACAGCCATC CTTGAATCAA TTGAAAAAGA AGAAAACATG GGACAATATA TAGAATATAA GGATCATATC AAGGATATGA TTAAATACTA TGGAATTTTG GACCCACCAT TGATTGCCAA TGGATTGATA ACACTCATTG AAGATGATGC TTTAAATGGT GCTATTATGA AGATCACAAC TTCTAAGGGA ATTCATTTTC AAGACTATGA TACAACTCCA TTTCAAGCAA AAACCCAATG A T ranslation Sequence: MHVNGKVALV TGAAQGIGRA FAEALLLKGA KVALVDWNLE AGVQCKAALD EQFEPQKTLF IQCDVADQQQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW EKTLQINLVS VISGTYLGLD YMSKQNGGEG GIIINMSSLA GLMPVAQQPV YCASKHGIVG FTRSAALAAN LMNSGVRLNA ICPGFVNTAI LESIEKEENM GQYIEYKDHI KDMIKYYGIL DPPLIANGLI TLIEDDALNG AIMKITTSKG IHFQDYDTTP FQAKTQ. It is sometimes possible for the material contained within the vial of "HPGD, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
