ARL2BP cdna clone

ARL2BP

Cat. Num. AAA200587

• Gene Names: ARL2BP; BART; RP66; BART1
• Synonyms: ARL2BP; BART; BART1; RP66; ARL2BP cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGGACGCCT TAGAAGGAGA GAGCTTTGCG CTGTCTTTCT CCTCCGCCTC TGATGCAGAA TTTGATGCTG TGGTTGGATA TTTAGAGGAC ATTATCATGG ATGACGAGTT CCAGTTATTA CAGAGAAATT TCATGGACAA GTACTACCTG GAGTTTGAAG ACACAGAAGA GAATAAACTC ATCTACACAC CTATTTTTAA TGAATACATT TCTTTGGTAG AAAAATACAT TGAAGAACAG CTGCTGCAGC GGATTCCTGA GTTCAACATG GCAGCCTTCA CCACAACATT ACAGCACCAT AAGGATGAAG TGGCTGGTGA CATATTCGAC ATGCTGCTCA CCTTCACAGA TTTTCTGGCT TTTAAAGAAA TGTTTTTGGA CTACAGAGCA GAAAAAGAAG GCCGAGGACT GGACTTAAGC AGTGGCTTAG TGGTGACTTC ATTGTGCAAA TCATCTTCTC TGCCAGCTTC CCAGAACAAT CTGCGGCACT AG; ; Translation Sequence: MDALEGESFA LSFSSASDAE FDAVVGYLED IIMDDEFQLL QRNFMDKYYL EFEDTEENKL IYTPIFNEYI SLVEKYIEEQ LLQRIPEFNM AAFTTTLQHH KDEVAGDIFD MLLTFTDFLA FKEMFLDYRA EKEGRGLDLS SGLVVTSLCK SSSLPASQNN LRH
• Sequence Length: 163

• Species: Human
• Chromosome Location: 16q13
• OMIM Reference Number: 615407
• cDNA Size: 492bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for ARL2BP cdna clone

ARL2BP is an effector of ADP-ribosylation factor-like 2 (ARL2) that is essential for nuclear retention of STAT3. This protein binds to ARL2. GTP with high affinity but does not interact with ARL2. GDP, activated ARF, or RHO proteins. Though predominantly cytosolic, ARL2BP can enter the mitochondria and bind the adenine nucleotide transporter when bound to ARL2. Thus it may also be involved in mitochondria transport and apoptosis.

Product Categories/Family for ARL2BP cdna clone

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 6912268
• NCBI GeneID: 23568
• NCBI Accession #: NP_036238.1
• NCBI GenBank Nucleotide #: NM_012106.3
• UniProt Accession #: Q9Y2Y0
• NCBI Official Full Name: ADP-ribosylation factor-like protein 2-binding protein
• NCBI Official Synonym Full Names: ADP ribosylation factor like GTPase 2 binding protein
• NCBI Official Symbol: ARL2BP
• NCBI Official Synonym Symbols: BART; RP66; BART1
• NCBI Protein Information: ADP-ribosylation factor-like protein 2-binding protein
• UniProt Protein Name: ADP-ribosylation factor-like protein 2-binding protein
• Protein Family: ADP-ribosylation factor-like protein 2-binding protein
• UniProt Gene Name: ARL2BP
• UniProt Synonym Gene Names: BART; BART1; ARF-like 2-binding protein
• UniProt Entry Name: AR2BP_HUMAN

NCBI Description

ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]

Uniprot Description

ARL2BP: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. Belongs to the ARL2BP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein regulator, misc.; Mitochondrial

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: centrosome; mitochondrial intermembrane space; spindle; midbody; nucleus; cilium

Molecular Function: protein binding; transcription coactivator activity

Biological Process: regulation of catalytic activity; maintenance of protein localization in nucleus; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein

Disease: Retinitis Pigmentosa With Or Without Situs Inversus