CCS cdna clone

CCS

Cat. Num. AAA200584

• Synonyms: CCS; CCS cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGGCTTCGG ATTCGGGGAA CCAGGGGACC CTCTGCACGT TGGAGTTCGC GGTGCAGATG ACCTGTCAGA GCTGTGTGGA CGCGGTGCGC AAATCCCTGC AAGGGGTGGC AGGTGTCCAG GATGTGGAGG TGCACTTGGA GGACCAGATG GTCTTGGTAC ACACCACTCT ACCCAGCCAG GAGGTGCAGG CTCTCCTGGA AGGCACGGGG CGGCAGGCGG TACTCAAGGG CATGGGCAGC GGCCAGTTGC AGAATCTGGG GGCAGCAGTG GCCATCCTGG GGGGGCCTGG CACCGTGCAG GGGGTGGTGC GCTTCCTACA GCTGACCCCT GAGCGCTGCC TCATCGAGGG AACTATTGAC GGCCTGGAGC CTGGGCTGCA TGGACTCCAC GTCCATCAGT ACGGGGACCT TACAAACAAC TGCAACAGCT GTGGGAATCA CTTTAACCCT GATGGAGCAT CTCATGGGGG CCCCCAGGAC TCTGACCGGC ACCGCGGAGA CCTGGGCAAT GTCCGTGCTG ATGCTGACGG CCGCGCCATC TTCAGAATGG AGGATGAGCA GCTGAAGGTG TGGGATGTGA TTGGCCGCAG CCTGATTATT GATGAGGGAG AAGATGACCT GGGCCGGGGA GGCCATCCCT TATCCAAGAT CACAGGGAAC TCCGGGGAGA GGTTGGCCTG TGGCATCATT GCACGCTCCG CTGGCCTTTT CCAGAACCCC AAGCAGATCT GCTCTTGCGA TGGCCTCACC ATCTGGGAGG AGCGAGGCCG GCCCATCGCT GGCAAGGGCC GAAAGGAGTC AGCGCAGCCC CCTGCCCACC TTTGA; ; Translation Sequence: MASDSGNQGT LCTLEFAVQM TCQSCVDAVR KSLQGVAGVQ DVEVHLEDQM VLVHTTLPSQ EVQALLEGTG RQAVLKGMGS GQLQNLGAAV AILGGPGTVQ GVVRFLQLTP ERCLIEGTID GLEPGLHGLH VHQYGDLTNN CNSCGNHFNP DGASHGGPQD SDRHRGDLGN VRADADGRAI FRMEDEQLKV WDVIGRSLII DEGEDDLGRG GHPLSKITGN SGERLACGII ARSAGLFQNP KQICSCDGLT IWEERGRPIA GKGRKESAQP PAHL
• Sequence Length: 274

• Species: Human
• Chromosome Location: 11q13
• OMIM Reference Number: 603864
• cDNA Size: 825bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for CCS cdna clone

CCS is essential for the incorporation of copper into SOD-1, and therefore is necessary for its enzymatic activity. CCS prevents copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the necessary copper cofactor. CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system.

Product Categories/Family for CCS cdna clone

Cancer; Metabolism; Transportation

NCBI and Uniprot Product Information

• NCBI GI #: 4826665
• NCBI GeneID: 9973
• NCBI Accession #: NP_005116.1
• NCBI GenBank Nucleotide #: NM_005125.1
• UniProt Accession #: O14618
• NCBI Official Full Name: copper chaperone for superoxide dismutase
• NCBI Official Synonym Full Names: copper chaperone for superoxide dismutase
• NCBI Official Symbol: CCS
• NCBI Protein Information: copper chaperone for superoxide dismutase
• UniProt Protein Name: Copper chaperone for superoxide dismutase
• Protein Family: Capsanthin/capsorubin synthase
• UniProt Gene Name: CCS
• UniProt Entry Name: CCS_HUMAN

NCBI Description

Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]

Uniprot Description

CCS: Delivers copper to copper zinc superoxide dismutase (SOD1).

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: copper ion transmembrane transporter activity; protein binding; copper ion binding; zinc ion binding; superoxide dismutase activity; protein disulfide oxidoreductase activity

Biological Process: response to reactive oxygen species; removal of superoxide radicals; superoxide metabolic process; intracellular copper ion transport; positive regulation of oxidoreductase activity