NAA10 cdna clone

NAA10

Cat. Num. AAA200581

• Gene Names: NAA10; TE2; ARD1; NATD; ARD1A; ARD1P; OGDNS; hARD1; DXS707; MCOPS1
• Synonyms: NAA10; ARD1; ARD1A; ARD1P; DXS707; MCOPS1; NATD; TE2; NAA10 cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGAACATCC GCAATGCGAG GCCAGAGGAC CTAATGAACA TGCAGCACTG CAACCTCCTC TGCCTGCCCG AGAACTACCA GATGAAATAC TACTTCTACC ATGGCCTTTC CTGGCCCCAG CTCTCTTACA TTGCTGAGGA CGAGAATGGG AAGATTGTGG GGTATGTCCT GGCCAAAATG GAAGAGGACC CAGATGATGT GCCCCATGGA CATATCACCT CATTGGCTGT GAAGCGTTCC CACCGGCGCC TCGGTCTGGC TCAGAAACTG ATGGACCAGG CCTCTCGAGC CATGATAGAG AACTTCAATG CCAAATATGT CTCCCTGCAT GTCAGGAAGA GTAACCGGGC CGCCCTGCAC CTCTATTCCA ACACCCTCAA CTTTCAGATC AGTGAAGTGG AGCCCAAATA CTATGCAGAT GGGGAGGACG CCTATGCCAT GAAGCGGGAC CTCACTCAGA TGGCCGACGA GCTGAGGCGG CACCTGGAGC TGAAAGAGAA GGGCAGGCAC GTGGTGCTGG GTGCCATCGA GAACAAGGTG GAGAGCAAAG GCAATTCACC TCCGAGCTCA GGAGAGGCCT GTCGCGAGGA GAAGGGCCTG GCTGCCGAGG ATAGTGGTGG GGACAGCAAG GACCTCAGCG AGGTCAGCGA GACCACAGAG AGCACAGATG TCAAGGACAG CTCAGAGGCC TCCGACTCAG CCTCCTAG; ; Translation Sequence: MNIRNARPED LMNMQHCNLL CLPENYQMKY YFYHGLSWPQ LSYIAEDENG KIVGYVLAKM EEDPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE NFNAKYVSLH VRKSNRAALH LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD LTQMADELRR HLELKEKGRH VVLGAIENKV ESKGNSPPSS GEACREEKGL AAEDSGGDSK DLSEVSETTE STDVKDSSEA SDSAS
• Sequence Length: 235

• Species: Human
• Chromosome Location: Xq28
• OMIM Reference Number: 300013
• cDNA Size: 708bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted Nde I to BamH I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for NAA10 cdna clone

NAA10 belongs to the acetyltransferase family. NAA10 interacts NAA15, HIF-1 with the ribosome. In its binding to HIF-1, NAA10 acts as a protein acetyltransferase by regulating its stability. In many cell lines, NAA10 is downregulated in response to hypoxia. NAA10 is expressed throughout the development of the brain.

Product Categories/Family for NAA10 cdna clone

Metabolism; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 10835057
• NCBI GeneID: 8260
• NCBI Accession #: NP_003482.1
• NCBI GenBank Nucleotide #: NM_003491.3
• UniProt Accession #: P41227
• NCBI Official Full Name: N-alpha-acetyltransferase 10 isoform 1
• NCBI Official Synonym Full Names: N(alpha)-acetyltransferase 10, NatA catalytic subunit
• NCBI Official Symbol: NAA10
• NCBI Official Synonym Symbols: TE2; ARD1; NATD; ARD1A; ARD1P; OGDNS; hARD1; DXS707; MCOPS1
• NCBI Protein Information: N-alpha-acetyltransferase 10
• UniProt Protein Name: N-alpha-acetyltransferase 10
• Protein Family: N-alpha-acetyltransferase
• UniProt Gene Name: NAA10
• UniProt Synonym Gene Names: ARD1; ARD1A; TE2
• UniProt Entry Name: NAA10_HUMAN

NCBI Description

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Description

NAA10: In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, and down-regulates it when induced by hypoxia. Interacts with NAA15, NAA50 and with the ribosome. Binds to MYLK. Ubiquitous. Belongs to the acetyltransferase family. ARD1 subfamily.

Protein type: Amino Acid Metabolism - tyrosine; Secondary Metabolites Metabolism - limonene and pinene degradation; Amino Acid Metabolism - phenylalanine; EC 2.3.1.88; Lipid Metabolism - glycerophospholipid; Acetyltransferase

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: membrane; cytoplasm; nucleolus; intracellular; nucleus

Molecular Function: peptide alpha-N-acetyltransferase activity; N-acetyltransferase activity; protein binding; acetyltransferase activity; ribosome binding

Biological Process: N-terminal protein amino acid acetylation; N-terminal peptidyl-glutamic acid acetylation; internal protein amino acid acetylation; N-terminal peptidyl-serine acetylation; DNA packaging

Disease: Ogden Syndrome; Microphthalmia, Syndromic 1