Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Heart Tissue; Lane2: Mouse Liver Tissue; Lane3: Rat Brain Tissue.)
Rabbit anti-Mouse Superoxide Dismutase 2, Mitochondrial (SOD2) Polyclonal Antibody | anti-SOD2 antibody
Polyclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2)
MGHHHHHHSGS-KHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN NLNATEEKYH EALAKGDVTT QVALQPALKF NGGGHINHTI FWTNLSPKGG GEPKGELLEAIKRDFGSFEK FKEKLTAVSV GVQGSGWGWL GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY LKAIWNVINW ENVTERYTAC KK
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Heart Tissue; Lane2: Mouse Liver Tissue; Lane3: Rat Brain Tissue.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Heart Tissue; Lane2: Mouse Liver Tissue; Lane3: Rat Brain Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant SOD2, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant SOD2, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Spleen Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Spleen Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Stomach Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Stomach Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue.)
NCBI and Uniprot Product Information
Uniprot Description
SOD2: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.15.1.1; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 17 A1|17 8.75 cM
Cellular Component: cytoplasm; extracellular exosome; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; myelin sheath
Molecular Function: DNA binding; enzyme binding; identical protein binding; manganese ion binding; metal ion binding; oxidoreductase activity; oxygen binding; protein binding; superoxide dismutase activity
Biological Process: acetylcholine vasodilation involved in regulation of systemic arterial blood pressure; age-dependent response to oxidative stress; age-dependent response to reactive oxygen species; apoptotic mitochondrial changes; detection of oxygen; DNA damage response, signal transduction resulting in induction of apoptosis; erythrophore differentiation; glutathione metabolic process; heart development; hemopoiesis; hydrogen peroxide biosynthetic process; hydrogen peroxide metabolic process; induction of apoptosis by oxidative stress; iron ion homeostasis; liver development; locomotory behavior; mitochondrion organization; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of fibroblast proliferation; negative regulation of neuron apoptosis; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; neuron development; oxygen homeostasis; positive regulation of cell migration; positive regulation of nitric oxide biosynthetic process; post-embryonic development; protein homooligomerization; protein homotetramerization; regulation of blood pressure; regulation of catalytic activity; regulation of mitochondrial membrane potential; regulation of transcription from RNA polymerase II promoter; release of cytochrome c from mitochondria; removal of superoxide radicals; response to activity; response to axon injury; response to drug; response to gamma radiation; response to hydrogen peroxide; response to hyperoxia; response to nutrient levels; response to oxidative stress; response to reactive oxygen species; response to superoxide; sensory perception of sound; superoxide anion generation; superoxide metabolic process; vasodilation
Research Articles on SOD2
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Product Notes
The SOD2 sod2 (Catalog #AAA2003840) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Superoxide Dismutase 2, Mitochondrial (SOD2) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the SOD2 sod2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with a His-tag and its sequence is listed below. MGHHHHHHSG S-KHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN NLNATEEKYH EALAKGDVTT QVALQPALKF NGGGHINHTI FWTNLSPKGG GEPKGELLEA IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY LKAIWNVINW ENVTERYTAC KK. It is sometimes possible for the material contained within the vial of "Superoxide Dismutase 2, Mitochondrial (SOD2), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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