Rabbit anti-Human Growth Hormone Releasing Hormone (GHRH) Polyclonal Antibody | anti-GHRH antibody

Biotin-Linked Antibody to Growth Hormone Releasing Hormone (GHRH)

Cat. Num. AAA2003181

• Gene Names: GHRHR; GRFR; GHRFR; IGHD1B
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Affinity Chromatography
• Synonyms: Growth Hormone Releasing Hormone (GHRH); Polyclonal Antibody; Biotin-Linked Antibody to Growth Hormone Releasing Hormone (GHRH); anti-GHRH antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody is a rabbit polyclonal antibody raised against GHRH conjugated to biotin. It has been selected for its ability to recognize GHRH in immunohistochemical staining andwestern blotting.
• Purity/Purification: Affinity Chromatography
• Form/Format: Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
• Concentration: 500ug/ml (varies by lot)
• Sequence Length: 235

• Applicable Applications for anti-GHRH antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: Western blotting: 1:100-400; Immunocytochemistry in formalin fixed cells: 1:100-500; Immunohistochemistry in formalin fixed frozen section: 1:100-500; Immunohistochemistry in paraffin section: 1:50-200; Enzyme-linked Immunosorbent Assay: 1:100-200
• Preparation and Storage: Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Product Categories/Family for anti-GHRH antibody

Biotin Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 1706945
• NCBI GeneID: 2692
• UniProt Accession #: Q02643; Q99863
• Molecular Weight: 47,402 Da
• NCBI Official Full Name: growth hormone releasing hormone, partial
• NCBI Official Synonym Full Names: growth hormone releasing hormone receptor
• NCBI Official Symbol: GHRHR
• NCBI Official Synonym Symbols: GRFR; GHRFR; IGHD1B
• NCBI Protein Information: growth hormone-releasing hormone receptor; GRF receptor; GHRH receptor
• UniProt Protein Name: Growth hormone-releasing hormone receptor
• Protein Family: Somatoliberin
• UniProt Gene Name: GHRHR
• UniProt Synonym Gene Names: GHRH receptor; GRF receptor; GRFR
• UniProt Entry Name: GHRHR_HUMAN

NCBI Description

This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]

Uniprot Description

GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family.

Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; Cell development/differentiation

Chromosomal Location of Human Ortholog: 7p14

Cellular Component: nuclear outer membrane; nuclear matrix; cell surface; cytoplasm; integral to membrane; plasma membrane; nuclear inner membrane; secretory granule

Molecular Function: G-protein coupled receptor activity; protein binding; growth factor binding; peptide hormone binding; growth hormone-releasing hormone receptor activity

Biological Process: lactation; positive regulation of insulin-like growth factor receptor signaling pathway; adenylate cyclase activation; regulation of protein metabolic process; cell maturation; response to glucocorticoid stimulus; positive regulation of multicellular organism growth; determination of adult life span; reproductive process in a multicellular organism; G-protein signaling, adenylate cyclase activating pathway; response to insulin stimulus; water homeostasis; positive regulation of growth hormone secretion; growth hormone secretion; cAMP-mediated signaling; cellular response to insulin stimulus; response to estrogen stimulus; positive regulation of cell proliferation; somatotropin secreting cell development; positive regulation of cAMP biosynthetic process; hormone metabolic process; regulation of steroid hormone receptor signaling pathway

Disease: Isolated Growth Hormone Deficiency, Type Ib