Porcine Growth Hormone Releasing Hormone ELISA Kit | GHRH elisa kit

Porcine Growth Hormone Releasing Hormone ELISA Kit

Cat. Num. AAA761314

• Gene Names: GHRHR; GRFR; GHRFR; IGHD1B
• Reactivity: Porcine
• Synonyms: Growth Hormone Releasing Hormone; Porcine Growth Hormone Releasing Hormone ELISA Kit; GHRH elisa kit

• Reactivity: Porcine
• Sequence Length: 235

• Samples: Serum, plasma and other biological fluids.
• Assay Type: Sandwich ELISA, Double Antibody
• Detection Range: 15.625-1000pg/ml
• Sensitivity: 9.375pg/ml
• Preparation and Storage: Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).

Typical Standard Curve

NCBI and Uniprot Product Information

• NCBI GI #: 1706945
• NCBI GeneID: 2692
• Molecular Weight: 47,402 Da
• NCBI Official Full Name: growth hormone releasing hormone, partial
• NCBI Official Synonym Full Names: growth hormone releasing hormone receptor
• NCBI Official Symbol: GHRHR
• NCBI Official Synonym Symbols: GRFR; GHRFR; IGHD1B
• NCBI Protein Information: growth hormone-releasing hormone receptor
• UniProt Protein Name: Growth hormone-releasing hormone receptor
• Protein Family: Somatoliberin
• UniProt Gene Name: GHRHR
• UniProt Synonym Gene Names: GHRH receptor; GRF receptor; GRFR
• UniProt Entry Name: GHRHR_HUMAN

NCBI Description

This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]

Uniprot Description

GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; Cell development/differentiation; GPCR, family 2

Chromosomal Location of Human Ortholog: 7p14

Cellular Component: cell surface; cytoplasm; integral to membrane; nuclear inner membrane; nuclear matrix; nuclear outer membrane; plasma membrane; sarcolemma; secretory granule

Molecular Function: G-protein coupled receptor activity; growth factor binding; growth hormone-releasing hormone receptor activity; peptide hormone binding; protein binding

Biological Process: adenylate cyclase activation; cAMP-mediated signaling; cell maturation; cell surface receptor linked signal transduction; cellular response to insulin stimulus; determination of adult life span; G-protein signaling, adenylate cyclase activating pathway; growth hormone secretion; hormone metabolic process; lactation; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of growth hormone secretion; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of protein metabolic process; regulation of steroid hormone receptor signaling pathway; reproductive process in a multicellular organism; response to estrogen stimulus; response to glucocorticoid stimulus; response to insulin stimulus; somatotropin secreting cell development; water homeostasis

Disease: Isolated Growth Hormone Deficiency, Type Ib