Rabbit IRAK-4 Polyclonal Antibody | anti-IRAK4 antibody

IRAK-4 Polyclonal Antibody

Cat. Num. AAA194277

• Gene Names: IRAK4; IPD1; REN64; NY-REN-64
• Applications: Western Blot
• Synonyms: IRAK-4; Polyclonal Antibody; IRAK-4 Polyclonal Antibody; anti-IRAK4 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: IRAK-4 [Rabbit polyclonal antibody to IRAK-4]; This antibody specifically recognizes human IRAK-4 (IL-1 Receptor Associated Kinase). IRAK-4 activates the NF- kappa B and MAPK pathways, and plays a role in IL-1R mediated inflammatory responses and innate immunity. Anti-IRAK-4 does not crossreact with other IRAKs.
• Form/Format: 100 ug IgG in PBS, pH 7.4,purified by immunoaffinity chromatography.

• Applicable Applications for anti-IRAK4 antibody: Western Blot
• Application Notes: Western Blot: Use at 1-2 ug/ml. A band of approximately 50 kD is detected using HeLa Cell Lysate as a positive control.
• Antigen: A synthetic peptide corresponding to the carboxy terminus of human IRAK-4.
• Stabilizer: None
• Preservatives: 0.02% sodium azide
• Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: Store at 4 degree C; stable for one year

Product Categories/Family for anti-IRAK4 antibody

Neuroscience and Signal Transduction Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 166795295
• NCBI GeneID: 51135
• NCBI Accession #: NP_001107654.1
• NCBI GenBank Nucleotide #: NM_001114182.2
• UniProt Accession #: Q69FE3; Q7Z6A7; Q7Z6A8; Q9NWZ3
• Molecular Weight: 51,530 Da
• NCBI Official Full Name: interleukin-1 receptor-associated kinase 4 isoform a
• NCBI Official Synonym Full Names: interleukin-1 receptor-associated kinase 4
• NCBI Official Symbol: IRAK4
• NCBI Official Synonym Symbols: IPD1; REN64; NY-REN-64
• NCBI Protein Information: interleukin-1 receptor-associated kinase 4; IRAK-4; renal carcinoma antigen NY-REN-64
• UniProt Protein Name: Interleukin-1 receptor associated kinase-4
• Protein Family: Interleukin-1 receptor-associated kinase
• UniProt Gene Name: IRAK4
• UniProt Entry Name: Q69FE3_HUMAN

NCBI Description

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq]

Uniprot Description

IRAK4: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.

Protein type: Kinase, protein; Protein kinase, TKL; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); TKL group; IRAK family

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: extracellular space; cytoplasm; plasma membrane; endosome membrane; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; interleukin-1 receptor binding; magnesium ion binding; ATP binding; protein kinase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of smooth muscle cell proliferation; cytokine and chemokine mediated signaling pathway; cytokine production; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor signaling pathway; JNK cascade; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway

Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Irak4 Deficiency