Mouse anti-Rat CD8a Monoclonal Antibody | anti-CD8a antibody
Anti-Rt CD8a Purified
Reactivity
Rat
Applications
Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot, Immunohistochemistry
Purity
Purified by Protein-A Affinity Chromatography
Synonyms
CD8a; Monoclonal Antibody; Anti-Rt CD8a Purified; CD8a molecule; Ly-2; Ly-B; Ly-35; Lyt-2; anti-CD8a antibody
Host
Mouse
Reactivity
Rat
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
OX-8
Specificity
The mouse monoclonal antibody OX-8 recognizes the hinge-like membrane-proximal extracellular domain of rat CD8a (32-34 kDa; alpha chain of the CD8 antigen).
Purity/Purification
Purified by Protein-A Affinity Chromatography
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration
1 mg/ml (varies by lot)
Sequence Length
236
Applicable Applications for anti-CD8a antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB), Immunohistochemistry (IHC) Frozen/Paraffin
Application Notes
FC/FACS: QC tested
Immunogen
High Mw glycoproteins from rat thymocytes
Preparation and Storage
Store at 2-8 degree C.
Related Product Information for anti-CD8a antibody
The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
T-cell surface glycoprotein CD8 alpha chain
NCBI Official Synonym Full Names
CD8a molecule
NCBI Official Symbol
Cd8a
NCBI Protein Information
T-cell surface glycoprotein CD8 alpha chain
UniProt Protein Name
T-cell surface glycoprotein CD8 alpha chain
Protein Family
UniProt Gene Name
Cd8a
UniProt Entry Name
CD8A_RAT
NCBI Description
increased expression on mast cells is induced by nitric oxide; may play a role in inflammatory response [RGD, Feb 2006]
Uniprot Description
Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
Research Articles on CD8a
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Product Notes
The CD8a cd8a (Catalog #AAA1801439) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Rt CD8a Purified reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CD8a can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB), Immunohistochemistry (IHC) Frozen/Paraffin. FC/FACS: QC tested. Researchers should empirically determine the suitability of the CD8a cd8a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD8a, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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