anti-Rat IL13 Polyclonal Antibody | anti-IL13 antibody

Anti-IL13 Antibody

Cat. Num. AAA178098

• Reactivity: Rat
• Applications: ELISA
• Purity: Immunogen Affinity Purified
• Synonyms: IL13; Polyclonal Antibody; Anti-IL13 Antibody; Interleukin-13; Allergic rhinitis; ALRH; BHR1; Bronchial hyperresponsiveness 1 (bronchial asthma); IL 13; IL-13; Il13; IL13_HUMAN; Interleukin 13; MGC116786; MGC116788; MGC116789; NC30; P600; interleukin 13; anti-IL13 antibody

• Reactivity: Rat
• Clonality: Polyclonal
• Purity/Purification: Immunogen Affinity Purified
• Form/Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Sequence Length: 131

• Applicable Applications for anti-IL13 antibody: ELISA (EIA)
• Immunogen: E Coli-derived rat IL13 recombinant protein (Position: P22-H131). Rat IL13 shares 62% and 76% amino acid (aa) sequence identity with human and mouse IL13, respectively.
• Ig Type: Rabbit IgG
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Related Product Information for anti-IL13 antibody

Description: Rabbit IgG polyclonal antibody for Interleukin-13(IL13) detection. Tested with ELISA in Rat.

Background: IL-13, Interleukin 13, is a protein that in humans is encoded by the IL-13 gene. IL-13 is a kind of cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, which is an important mediator of allergic inflammation and disease. The IL-13 gene is mapped to 5q23-q31. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Ralpha) and at least one of two known IL-13-specific binding chains. This gene acts more prominently as a molecular bridge linking allergic inflammatory cells to the non-immune cells in contact with them, thereby altering physiological function.

References

1. Blackburn, M. R., Lee, C. G., Young, H. W. J., Zhu, Z., Chunn, J. L., Kang, M. J., Banerjee, S. K., Elias, J. A.Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. 2. Paul, W. E.Personal Communication.Bethesda, Md. 3/6/1993. 3. Punnonen, J., Aversa, G., Cocks, B. G., McKenzie, A. N. J., Menon, S., Zurawski, G., de Waal Malefyt, R., de Vries, J. E.Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.Proc. Nat. Acad. Sci. 90: 3730-3734, 1993.

NCBI and Uniprot Product Information

• NCBI GI #: 16758680
• NCBI GeneID: 116553
• NCBI Accession #: NP_446280.1
• NCBI GenBank Nucleotide #: NM_053828.1
• UniProt Accession #: P42203
• Molecular Weight: 14,093 Da
• NCBI Official Full Name: interleukin-13
• NCBI Official Synonym Full Names: interleukin 13
• NCBI Official Symbol: Il13
• NCBI Protein Information: interleukin-13
• UniProt Protein Name: Interleukin-13
• Protein Family: Interleukin
• UniProt Gene Name: Il13
• UniProt Synonym Gene Names: Il-13; IL-13
• UniProt Entry Name: IL13_RAT

NCBI Description

cytokine; involved in inflammatory and immune responses [RGD, Feb 2006]

Uniprot Description

IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: cytoplasm; external side of plasma membrane; extracellular region; extracellular space

Molecular Function: cytokine activity; interleukin-13 receptor binding

Biological Process: immune response; inflammatory response; microglial cell activation; negative regulation of NAD(P)H oxidase activity; positive regulation of B cell proliferation; positive regulation of connective tissue growth factor production; positive regulation of immunoglobulin production; positive regulation of ion transport; positive regulation of macrophage activation; positive regulation of mast cell degranulation; positive regulation of protein secretion; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of smooth muscle cell proliferation; positive regulation of tyrosine phosphorylation of Stat6 protein; regulation of proton transport; response to ethanol; response to lipopolysaccharide; response to mechanical stimulus; response to nicotine