Western Blot (WB)
(Anti- KAT13A antibody, Western blottingAll lanes: Anti KAT13A at 0.5ug/mlLane 1: COLO320 Whole Cell Lysate at 40ugLane 2: A549 Whole Cell Lysate at 40ugPredicted bind size: 60KDObserved bind size: 60KD)
anti-Human KAT13A/SRC1 Polyclonal Antibody | anti-KAT13A/SRC1 antibody
Anti-KAT13A/SRC1 Antibody
Western Blot (WB)
(Anti- KAT13A antibody, Western blottingAll lanes: Anti KAT13A at 0.5ug/mlLane 1: COLO320 Whole Cell Lysate at 40ugLane 2: A549 Whole Cell Lysate at 40ugPredicted bind size: 60KDObserved bind size: 60KD)
Western Blot (WB)
(Anti- KAT13A antibody, Western blottingAll lanes: Anti KAT13A at 0.5ug/mlLane 1: COLO320 Whole Cell Lysate at 40ugLane 2: A549 Whole Cell Lysate at 40ugPredicted bind size: 60KDObserved bind size: 60KD)
Background: The nuclear receptor coactivator 1 (NCOA1), also known as SRC1, is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression. It has been found that NCOA1 can enhance the transcriptional activity of ligand-bound PGR but does not alter the basal activity of the target promoter. It also enhances estrogen receptor, glucocorticoid receptor, thyroid hormone receptor, and retinoid X receptor transcriptional activities through their cognate DNA response elements in the presence of hormone. What's more, SRC1 may play a role as a bridging molecule between nuclear hormone receptors and general transcription factors.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
SRC-1: a transcriptional coactivator for steroid and nuclear hormone receptors. A member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, and bHLH and PAS domains. Phosphorylated and activated via the mitogen-activated protein kinase pathway. Three alternatively spliced isoforms have been described.
Protein type: DNA-binding; Nuclear receptor co-regulator; EC 2.3.1.48; Transcription, coactivator/corepressor; Oncoprotein; Acetyltransferase
Chromosomal Location of Human Ortholog: 2p23
Cellular Component: cytoplasm; neuron projection; nuclear chromatin; nucleoplasm
Molecular Function: androgen receptor binding; chromatin binding; enzyme binding; estrogen receptor binding; histone acetyltransferase activity; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; progesterone receptor binding; protein binding; protein complex binding; protein dimerization activity; protein N-terminus binding; retinoid X receptor binding; transcription coactivator activity
Biological Process: androgen receptor signaling pathway; bile acid and bile salt transport; cellular lipid metabolic process; cellular response to hormone stimulus; cerebellum development; cerebral cortex development; hippocampus development; hypothalamus development; intracellular receptor-mediated signaling pathway; lactation; male gonad development; male mating behavior; positive regulation of apoptosis; positive regulation of female receptivity; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by galactose; positive regulation of transcription, DNA-dependent; response to estradiol stimulus; response to progesterone stimulus; response to retinoic acid; transcription, DNA-dependent
Research Articles on KAT13A/SRC1
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Product Notes
The KAT13A/SRC1 ncoa1 (Catalog #AAA177991) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-KAT13A/SRC1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KAT13A/SRC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the KAT13A/SRC1 ncoa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KAT13A/SRC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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