Western Blot (WB)
(Anti- FOXM1 antibody, MBS177412, Western blottingAll lanes: Anti FOXM1 (MBS177412) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: COLO320 Whole Cell Lysate at 40ugLane 3: SW620 Whole Cell Lysate at 40ugLane 4: SKOV Whole Cell Lysate at 40ugLane 5: MCD-7 Whole Cell Lysate at 40ugPredicted bind size: 84KDObserved bind size: 84KD )
Rabbit Forkhead box protein M1 Polyclonal Antibody | anti-FOXM1 antibody
Anti-FOXM1 Antibody
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Western Blot (WB)
(Anti- FOXM1 antibody, MBS177412, Western blottingAll lanes: Anti FOXM1 (MBS177412) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: COLO320 Whole Cell Lysate at 40ugLane 3: SW620 Whole Cell Lysate at 40ugLane 4: SKOV Whole Cell Lysate at 40ugLane 5: MCD-7 Whole Cell Lysate at 40ugPredicted bind size: 84KDObserved bind size: 84KD )
Western Blot (WB)
(Anti- FOXM1 antibody, MBS177412, Western blottingAll lanes: Anti FOXM1 (MBS177412) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: COLO320 Whole Cell Lysate at 40ugLane 3: SW620 Whole Cell Lysate at 40ugLane 4: SKOV Whole Cell Lysate at 40ugLane 5: MCD-7 Whole Cell Lysate at 40ugPredicted bind size: 84KDObserved bind size: 84KD )
Western Blot (WB)
(Anti- FOXM1 antibody, MBS177412, Western blottingAll lanes: Anti FOXM1 (MBS177412) at 0.5ug/mlWB: Recombinant Human FOXM1 Protein 0.5ngPredicted bind size: 36KDObserved bind size: 36KD )
Western Blot (WB)
(Anti- FOXM1 antibody, MBS177412, Western blottingAll lanes: Anti FOXM1 (MBS177412) at 0.5ug/mlWB: Recombinant Human FOXM1 Protein 0.5ngPredicted bind size: 36KDObserved bind size: 36KD )
Background: Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 "brain washes" normal cells to adopt cancer-like epigenome.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Uniprot Description
FOXM1: a transcriptional activator factor. Contains 1 fork-head domain. May play a role in the control of cell proliferation. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Phosphorylated in M (mitotic) phase. Three splice variant isoforms have been described. Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; protein kinase binding; transcription factor activity
Biological Process: regulation of Ras protein signal transduction; transcription from RNA polymerase II promoter; regulation of cell cycle; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; liver development; negative regulation of stress-activated MAPK cascade; DNA repair; cell cycle; regulation of cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth; mitotic cell cycle; vasculogenesis; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent
Research Articles on FOXM1
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Product Notes
The FOXM1 foxm1 (Catalog #AAA177412) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-FOXM1 Antibody reacts with Human. No cross reactivity with other proteins. and may cross-react with other species as described in the data sheet. AAA Biotech's Forkhead box protein M1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human. Researchers should empirically determine the suitability of the FOXM1 foxm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Forkhead box protein M1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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