Typical Testing Data/Standard Curve (for reference only)
(Human TNFRSF18/GITR PicoKine ELISA Kit standard curve )
Human TNFRSF18/GITR ELISA Kit | TNFRSF18 elisa kit
Human TNFRSF18/GITR PicoKine ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
(Human TNFRSF18/GITR PicoKine ELISA Kit standard curve )
Typical Testing Data/Standard Curve (for reference only)
(Human TNFRSF18/GITR PicoKine ELISA Kit standard curve )
Background: Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. This gene is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Uniprot Description
TNFRSF18: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Receptor, cytokine
Chromosomal Location of Human Ortholog: 1p36.3
Cellular Component: integral to plasma membrane; extracellular region; external side of plasma membrane
Molecular Function: tumor necrosis factor receptor activity
Biological Process: tumor necrosis factor-mediated signaling pathway; apoptosis; signal transduction; negative regulation of apoptosis
Research Articles on TNFRSF18
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Product Notes
The Human TNFRSF18 tnfrsf18 (Catalog #AAA177272) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA177272 ELISA Kit recognizes Human TNFRSF18. It is sometimes possible for the material contained within the vial of "TNFRSF18/GITR, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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