Western Blot (WB)
(Anti- DR3 antibody, MBS176242, Western blottingAll lanes: Anti DR3 (MBS176242) at 0.5ug/mlWB: COLO320 Whole Cell Lysate at 40ugPredicted bind size: 59KDObserved bind size: 59KD )
Rabbit anti-Human DR3 Polyclonal Antibody | anti-TNFRSF25 antibody
Anti-DR3 antibody
Western Blot (WB)
(Anti- DR3 antibody, MBS176242, Western blottingAll lanes: Anti DR3 (MBS176242) at 0.5ug/mlWB: COLO320 Whole Cell Lysate at 40ugPredicted bind size: 59KDObserved bind size: 59KD )
Western Blot (WB)
(Anti- DR3 antibody, MBS176242, Western blottingAll lanes: Anti DR3 (MBS176242) at 0.5ug/mlWB: COLO320 Whole Cell Lysate at 40ugPredicted bind size: 59KDObserved bind size: 59KD )
Background: TNFRSF25(Tumor Necrosis Factor Receptor Superfamily Member 25), also known as LARD, APO3, DR3 or TNFR25, is a protein that in humans is encoded by the TNFRSF25 gene. Members of the mammalian tumor necrosis factor receptor(TNFR) family are cell-surface proteins that interact with a corresponding TNF-related ligand family. By fluorescence in situ hybridization, Marsters et al.(1996) mapped the Apo3 gene to 1p36.3. Marsters et al.(1996) showed that ectopic expression of Apo3 in mammalian cells triggered apoptosis and activated the transcription factor NF-kappa-B. They suggested that, like TNFR1, Apo3 may regulate distinct signaling pathways in different cellular contexts.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]
Uniprot Description
TNFRSF25: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4. Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate. 12 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Apoptosis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.2
Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; cytosol
Molecular Function: tumor necrosis factor receptor activity; receptor activity
Biological Process: regulation of apoptosis; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; apoptosis; signal transduction
Research Articles on TNFRSF25
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Product Notes
The TNFRSF25 tnfrsf25 (Catalog #AAA176242) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-DR3 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DR3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TNFRSF25 tnfrsf25 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DR3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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