Western Blot (WB)
(Anti-Collagen IV antibody, MBS175589, Western blottingLane 1: Rat Kidney Tissue LysateLane 2: Rat Lung Tissue Lysate )
Rabbit Collagen IV Polyclonal Antibody | anti-COL4A2 antibody
Anti-Collagen IV antibody
Western Blot (WB)
(Anti-Collagen IV antibody, MBS175589, Western blottingLane 1: Rat Kidney Tissue LysateLane 2: Rat Lung Tissue Lysate )
Western Blot (WB)
(Anti-Collagen IV antibody, MBS175589, Western blottingLane 1: Rat Kidney Tissue LysateLane 2: Rat Lung Tissue Lysate )
Immunohistochemistry (IHC)
(Anti-Collagen IV antibody, MBS175589, IHC(F)IHC(F): Rat Kidney Tissue )
Immunohistochemistry (IHC)
(Anti-Collagen IV antibody, MBS175589, IHC(F)IHC(F): Rat Kidney Tissue )
Immunohistochemistry (IHC)
(Anti-Collagen IV antibody, MBS175589, IHC(P)IHC(P): Mouse Lung Tissue )
Immunohistochemistry (IHC)
(Anti-Collagen IV antibody, MBS175589, IHC(P)IHC(P): Mouse Lung Tissue )
Background: Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]
Uniprot Description
COL4A2: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A2 are the cause of porencephaly type 2 (POREN2). POREN2 is a neurologic disorder characterized by a fluid-filled cysts or cavities within the cerebral hemispheres. Affected individuals typically have hemiplegia, seizures, and intellectual disability. Porencephaly type 2, or schizencephalic porencephaly, is usually symmetric and represents a primary defect in the development of the cerebral ventricles. Defects in COL4A2 are a cause of susceptibility to intracerebral hemorrhage (ICH). ICH is a pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Belongs to the type IV collagen family.
Protein type: Secreted, signal peptide; Extracellular matrix; Secreted
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: extracellular matrix; intracellular membrane-bound organelle; endoplasmic reticulum lumen; collagen type IV; extracellular region
Molecular Function: protein binding; extracellular matrix structural constituent
Biological Process: collagen catabolic process; extracellular matrix disassembly; axon guidance; receptor-mediated endocytosis; negative regulation of angiogenesis; extracellular matrix organization and biogenesis; transcription, DNA-dependent; angiogenesis
Disease: Porencephaly 2; Hemorrhage, Intracerebral, Susceptibility To
Research Articles on COL4A2
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Product Notes
The COL4A2 col4a2 (Catalog #AAA175589) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Collagen IV antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Collagen IV can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin, Immunocytochemistry ICC. Researchers should empirically determine the suitability of the COL4A2 col4a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Collagen IV, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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