Mouse anti-Rat IL1RA Monoclonal Antibody | anti-Il1rn antibody
Anti-IL1RA Antibody (monoclonal, 12C13)
Gene Names
Il1rn; IL-1ra
Reactivity
Rat
Applications
ELISA
Purity
Immunogen affinity purified.
Synonyms
IL1RA; Monoclonal Antibody; Anti-IL1RA Antibody (monoclonal; 12C13); Interleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; IRAP; IL1 inhibitor; Il1rn; Il-1ra; interleukin 1 receptor antagonist; anti-Il1rn antibody
Host
Mouse
Reactivity
Rat
Clonality
Monoclonal
Isotype
Mouse IgG2b
Clone Number
12C13
Specificity
Mouse IgG monoclonal antibody for IL1RA detection.
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized. Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.
Applicable Applications for anti-Il1rn antibody
ELISA (EIA)(Cap)
Application Notes
ELISA(Cap)|1-5ug/ml|Rat|
Immunogen
E Coli-derived rat IL1RA recombinant protein (Position: H27-Q178). Rat IL1RA shares 77. 6% and 90. 7% amino acid (aa) sequence identity with human and mouse IL1RA, respectively.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Related Product Information for anti-Il1rn antibody
The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
References
1. "Entrez Gene: IL1RN interleukin 1 receptor antagonist".
2. Patterson D, Jones C, Hart I, Bleskan J, Berger R, Geyer D, Eisenberg SP, Smith MF, Arend WP (January 1993). "The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region". Genomics. 15 (1): 173-6.
3. Steinkasserer A, Spurr NK, Cox S, Jeggo P, Sim RB (July 1992). "The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci". Genomics. 13(3): 654-7.
2. Patterson D, Jones C, Hart I, Bleskan J, Berger R, Geyer D, Eisenberg SP, Smith MF, Arend WP (January 1993). "The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region". Genomics. 15 (1): 173-6.
3. Steinkasserer A, Spurr NK, Cox S, Jeggo P, Sim RB (July 1992). "The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci". Genomics. 13(3): 654-7.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
20,282 Da
NCBI Official Full Name
interleukin-1 receptor antagonist protein
NCBI Official Synonym Full Names
interleukin 1 receptor antagonist
NCBI Official Symbol
Il1rn
NCBI Official Synonym Symbols
IL-1ra
NCBI Protein Information
interleukin-1 receptor antagonist protein
UniProt Protein Name
Interleukin-1 receptor antagonist protein
Protein Family
UniProt Gene Name
Il1rn
UniProt Synonym Gene Names
Il-1ra; IL-1RN; IL-1ra; IRAP
UniProt Entry Name
IL1RA_RAT
Uniprot Description
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity ().
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Product Notes
The Il1rn il1rn (Catalog #AAA1753977) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-IL1RA Antibody (monoclonal, 12C13) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IL1RA can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(Cap). ELISA(Cap)|1-5ug/ml|Rat|. Researchers should empirically determine the suitability of the Il1rn il1rn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL1RA, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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