Western Blot (WB)
(Anti-mouse IL-10 antibody, MBS175362, Western blottingLane 1: Recombinant Mouse IL-10 Protein 10ngLane 2: Recombinant Mouse IL-10 Protein 5ngLane 3: Recombinant Mouse IL-10 Protein 2 )
Rabbit anti-Mouse IL10 Polyclonal Antibody | anti-IL10 antibody
Anti-mouse IL10 antibody
Western Blot (WB)
(Anti-mouse IL-10 antibody, MBS175362, Western blottingLane 1: Recombinant Mouse IL-10 Protein 10ngLane 2: Recombinant Mouse IL-10 Protein 5ngLane 3: Recombinant Mouse IL-10 Protein 2 )
Western Blot (WB)
(Anti-mouse IL-10 antibody, MBS175362, Western blottingLane 1: Recombinant Mouse IL-10 Protein 10ngLane 2: Recombinant Mouse IL-10 Protein 5ngLane 3: Recombinant Mouse IL-10 Protein 2 )
Background: Interleukin-10(IL-10 or IL10), also known as human cytokine synthesis inhibitory factor(CSIF), is an anti-inflammatory cytokine. In humans IL-10 is encoded by the IL10 gene. It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNFalpha and GM-CSF made by cells such as macrophages and regulatory T-cells.IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. Kim et al.(1992) showed that the mouse IL 10 gene contains 5 exons and spans about 5.2 kb of genomic DNA. Eskdale et al.(1997) mapped the IL10 gene to the junction between 1q31 and 1q32.
NCBI and Uniprot Product Information
Uniprot Description
IL10: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Belongs to the IL-10 family.
Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Cytokine
Cellular Component: extracellular space; extracellular region
Molecular Function: cytokine activity; interleukin-10 receptor binding
Biological Process: negative regulation of chronic inflammatory response to antigenic stimulus; positive regulation of transcription, DNA-dependent; response to glucocorticoid stimulus; positive regulation of JAK-STAT cascade; negative regulation of B cell proliferation; negative regulation of membrane protein ectodomain proteolysis; response to molecule of bacterial origin; negative regulation of interferon-gamma production; positive regulation of MHC class II biosynthetic process; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor biosynthetic process; inflammatory response; negative regulation of interleukin-12 production; positive regulation of B cell apoptosis; negative regulation of nitric oxide biosynthetic process; negative regulation of myeloid dendritic cell activation; negative regulation of tumor necrosis factor production; negative regulation of cytokine secretion during immune response; regulation of gene expression; negative regulation of inflammatory response; negative regulation of cytokine production; defense response to bacterium; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of transcription factor activity; receptor biosynthetic process; regulation of sensory perception of pain; positive regulation of cytokine secretion; negative regulation of apoptosis
Research Articles on IL10
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Product Notes
The IL10 il10 (Catalog #AAA175362) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-mouse IL10 antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IL10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). Researchers should empirically determine the suitability of the IL10 il10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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