Rabbit Annexin VI Polyclonal Antibody | anti-ANXA6 antibody

Anti-Annexin VI antibody

Cat. Num. AAA175188

• Gene Names: ANXA6; ANX6; CBP68
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunohistochemistry
• Purity: Immunogen affinity purified.
• Synonyms: Annexin VI; Polyclonal Antibody; Anti-Annexin VI antibody; Annexin A6; annexin A6; 67 kDa calelectrin antibody; Annexin A6 antibody; Annexin VI antibody; Annexin VI p68 antibody; Annexin-6 antibody; AnnexinA6 antibody; AnnexinVI antibody; ANX 6 antibody; ANX A6 antibody; ANX6 antibody; ANXA 6 antibody; ANXA6 antibody; ANXA6_HUMAN antibody; Calcium binding protein p68 antibody; Calelectrin antibody; Calphobindin II antibody; Calphobindin-II antibody; CalphobindinII antibody; CBP 68 antibody; CBP68 antibody; Chromobindin 20 antibody; Chromobindin-20 antibody; Chromobindin20 antibody; CPB II antibody; CPB-II antibody; CPBII antibody; Lipocortin VI antibody; LipocortinVI antibody; p68 antibody; p70 antibody; Protein III antibody; ProteinIII antibody; anti-ANXA6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 673

• Applicable Applications for anti-ANXA6 antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Annexin VI (636-652aa NIRREFIEKYDKSLHQA), identical to the related mouse and rat sequences.
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti-Annexin VI antibody, MBS175188, Western blottingLane 1: Rat Ovary Tissue LysateLane 2: Rat Liver Tissue LysateLane 3: Rat Intestinum Tenue Tissue LysateLane 4: Rat Brain Tissue LysateLane 5: A549 Cell LysateLane 6: JURKAT Cell LysateLane 7: RAJI Cell LysateLane 8: CEM Cell LysateLane 9: SMMC Cell Lysate )

Immunohistochemistry (IHC)

(Anti-Annexin VI antibody, MBS175188, IHC(P)IHC(P): Rat Spleen Tissue )

Immunohistochemistry (IHC)

(Anti-Annexin VI antibody, MBS175188, IHC(F)IHC(F): Rat Spleen Tissue )

Related Product Information for anti-ANXA6 antibody

Description: Rabbit IgG polyclonal antibody for Annexin A6(ANXA6) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.
Background: Annexin A6(ANXA6) is a member of a family of proteins that bind membrane or cytoskeleton in a Ca(2+)-dependent manner. These proteins are characterized by homologous amino acid sequences that are present in multiple copies in each protein. ANXA6 gene is assigned to 5q32-q34 by use of a cDNA clone to probe genomic DNA from rodent-human somatic cell hybrids and for in situ hybridization.The ANX6 gene is approximately 60 kb long and contains 26 exons. The genomic sequence at the 3-prime end does not contain a canonical polyadenylylation signal.Ca(2+)-dependent binding between CRHSP28 and ANXA6 is required for acinar cell membrane trafficking events and digestive enzyme secretion

NCBI and Uniprot Product Information

• NCBI GI #: 113962
• NCBI GeneID: 309
• UniProt Accession #: P08133; Q6ZT79; B7Z8A7; D3DQH4; E9PGK1
• Molecular Weight: 72,423 Da
• NCBI Official Full Name: Annexin A6
• NCBI Official Synonym Full Names: annexin A6
• NCBI Official Symbol: ANXA6
• NCBI Official Synonym Symbols: ANX6; CBP68
• NCBI Protein Information: annexin A6; p68; p70; CPB-II; annexin-6; calelectrin; lipocortin VI; calphobindin II; calphobindin-II; chromobindin-20; annexin VI (p68); 67 kDa calelectrin; calcium-binding protein p68
• UniProt Protein Name: Annexin A6
• Protein Family: Annexin
• UniProt Gene Name: ANXA6
• UniProt Synonym Gene Names: ANX6; CPB-II
• UniProt Entry Name: ANXA6_HUMAN

NCBI Description

Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

Uniprot Description

ANXA6: a calcium/phospholipid-binding protein that may associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Phosphorylated in response to growth factor stimulation. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Lipid-binding; Calcium-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: focal adhesion; membrane; lysosomal membrane; perinuclear region of cytoplasm; late endosome membrane; melanosome

Molecular Function: protein binding; protein homodimerization activity; GTP binding; calcium-dependent phospholipid binding; cholesterol binding; calcium ion binding; calcium-dependent protein binding; lipid binding; ligand-gated ion channel activity

Biological Process: regulation of muscle contraction; calcium ion transport; protein homooligomerization