Low Density Lipoprotein (LDL) Protein | LDL protein
Low Density Lipoprotein (LDL), Porcine Serum
Low-density lipoprotein (LDL) refers to a class and range of lipoprotein particles, varying in their size which carry cholesterol in the blood and around the body, for use by cells. Low Denisity Lipoprotein LDL contains the apolipoproteins B-100. Generally, Low Density Lipoprotein LDL transports cholesterol and triglycerides from the liver and small intestine to cells and tissues which are taking up cholesterol and triglycerides.
Human Low Density Lipoprotein LDL(s) transport cholesterol to the arteries, increased levels are associated with atherosclerosis, and thus heart attack, stroke and peripheral vascular disease.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]
Uniprot Description
LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung.
Protein type: Membrane protein, integral; Receptor, misc.; Cell surface; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: focal adhesion; cell soma; clathrin-coated vesicle; lysosomal membrane; integral to plasma membrane; dendrite; cytoplasm; nucleolus; plasma membrane; coated pit; endosome; receptor complex
Molecular Function: protein binding; lipoprotein transporter activity; protease binding; protein complex binding; apolipoprotein binding; calcium ion binding; receptor activity
Biological Process: cholesterol metabolic process; receptor-mediated endocytosis; phototransduction, visible light; regulation of phospholipase A2 activity; negative regulation of Wnt receptor signaling pathway; lipoprotein metabolic process; negative regulation of smooth muscle cell migration; positive regulation of protein transport; positive regulation of lipid transport; cell proliferation; lipoprotein transport; regulation of actin cytoskeleton organization and biogenesis; protein kinase C activation; negative regulation of neuron apoptosis; regulation of cholesterol transport; retinoid metabolic process; apoptotic cell clearance; aging
Research Articles on LDL
Similar Products
Product Notes
The LDL (Catalog #AAA173146) is a Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Low Density Lipoprotein (LDL), Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
