RHOQ recombinant protein

Recombinant Human RHOQ protein

Cat. Num. AAA1562679

• Gene Names: RHOQ; ARHQ; TC10; TC10A; RASL7A; HEL-S-42
• Purity: >90% as determined by SDS-PAGE
• Synonyms: RHOQ; Recombinant Human RHOQ protein; Rho-related GTP-binding protein RhoQ; Ras-like protein TC10; Ras-like protein family member 7A; RHOQ recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human RHOQ (Met1-Cys202) was fused with GST tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for RHOQ recombinant protein

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.

Product Categories/Family for RHOQ recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 50263042
• NCBI GeneID: 23433
• NCBI Accession #: NP_036381.2
• NCBI GenBank Nucleotide #: NM_012249.3
• UniProt Accession #: P17081; Q0VGN1; Q52LS8; Q53SJ1; Q6NS39; Q6P146; Q7Z480; D6W5A6
• Molecular Weight: 22,659 Da
• NCBI Official Full Name: rho-related GTP-binding protein RhoQ
• NCBI Official Synonym Full Names: ras homolog family member Q
• NCBI Official Symbol: RHOQ
• NCBI Official Synonym Symbols: ARHQ; TC10; TC10A; RASL7A; HEL-S-42
• NCBI Protein Information: rho-related GTP-binding protein RhoQ; RAS-like, family 7, member A; epididymis secretory protein Li 42; ras homolog gene family, member Q; ras-like protein TC10; ras-like protein family member 7A
• UniProt Protein Name: Rho-related GTP-binding protein RhoQ
• Protein Family: Rho-related GTP-binding protein
• UniProt Gene Name: RHOQ
• UniProt Synonym Gene Names: ARHQ; RASL7A; TC10
• UniProt Entry Name: RHOQ_HUMAN

NCBI Description

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]

Uniprot Description

RHOQ: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. Belongs to the small GTPase superfamily. Rho family.

Protein type: G protein, monomeric; G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: plasma membrane; actin filament; cytosol; lipid raft

Molecular Function: GTPase activity; GTP binding; GBD domain binding; profilin binding

Biological Process: positive regulation of filopodium formation; regulation of cell shape; positive regulation of glucose import; regulation of small GTPase mediated signal transduction; cellular response to insulin stimulus; metabolic process; regulation of actin cytoskeleton organization and biogenesis; small GTPase mediated signal transduction; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cortical actin cytoskeleton organization and biogenesis