ATP1B3 recombinant protein

Recombinant Human ATP1B3 protein

Cat. Num. AAA1562045

• Gene Names: ATP1B3; CD298; ATPB-3
• Purity: >90% as determined by SDS-PAGE
• Synonyms: ATP1B3; Recombinant Human ATP1B3 protein; Sodium/potassium-transporting ATPase subunit beta-3; Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3; CD298; ATP1B3 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human ATP1B3 (Met61-Phe273) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for ATP1B3 recombinant protein

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

Product Categories/Family for ATP1B3 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 4502281
• NCBI GeneID: 483
• NCBI Accession #: NP_001670.1
• NCBI GenBank Nucleotide #: NM_001679.2
• UniProt Accession #: P54709
• Molecular Weight: 31,513 Da
• NCBI Official Full Name: sodium/potassium-transporting ATPase subunit beta-3
• NCBI Official Synonym Full Names: ATPase, Na+/K+ transporting, beta 3 polypeptide
• NCBI Official Symbol: ATP1B3
• NCBI Official Synonym Symbols: CD298; ATPB-3
• NCBI Protein Information: sodium/potassium-transporting ATPase subunit beta-3; sodium pump subunit beta-3; Na, K-ATPase beta-3 polypeptide; sodium/potassium-dependent ATPase beta-3 subunit; sodium/potassium-dependent ATPase subunit beta-3; sodium/potassium-transporting ATPase beta
• UniProt Protein Name: Sodium/potassium-transporting ATPase subunit beta-3
• UniProt Gene Name: ATP1B3
• UniProt Synonym Gene Names: ATPB-3
• UniProt Entry Name: AT1B3_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

Uniprot Description

ATP1B3: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. Belongs to the X(+)/potassium ATPases subunit beta family.

Protein type: Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: melanosome; plasma membrane; caveola; sodium:potassium-exchanging ATPase complex

Molecular Function: ATPase activator activity; sodium:potassium-exchanging ATPase activity; ATPase binding

Biological Process: cellular sodium ion homeostasis; potassium ion import; protein stabilization; transport; positive regulation of ATPase activity; blood coagulation; cellular potassium ion homeostasis; leukocyte migration; transmembrane transport