IREB2 recombinant protein

Recombinant Human IREB2 protein

Cat. Num. AAA1561733

• Gene Names: IREB2; ACO3; IRP2; IRP2AD
• Purity: >90% as determined by SDS-PAGE
• Synonyms: IREB2; Recombinant Human IREB2 protein; Iron-responsive element-binding protein 2; IRE-BP 2; Iron regulatory protein 2; IRP2; IREB2 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human IREB2 (Pro39-Ser281) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for IREB2 recombinant protein

RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

Product Categories/Family for IREB2 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 41352693
• NCBI GeneID: 3658
• NCBI Accession #: NP_004127.1
• NCBI GenBank Nucleotide #: NM_004136.2
• UniProt Accession #: P48200; Q13095; Q1HE21; Q59FQ7; Q8WVK6; Q9UF17; A8KAC7; E1CJT9; H0YKU0
• Molecular Weight: 37,487 Da
• NCBI Official Full Name: iron-responsive element-binding protein 2
• NCBI Official Synonym Full Names: iron-responsive element binding protein 2
• NCBI Official Symbol: IREB2
• NCBI Official Synonym Symbols: ACO3; IRP2; IRP2AD
• NCBI Protein Information: iron-responsive element-binding protein 2; IRE-BP 2; iron regulatory protein 2
• UniProt Protein Name: Iron-responsive element-binding protein 2
• Protein Family: Iron-responsive element-binding protein
• UniProt Gene Name: IREB2
• UniProt Synonym Gene Names: IRE-BP 2; IRP2
• UniProt Entry Name: IREB2_HUMAN

Uniprot Description

IREB2: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. Belongs to the aconitase/IPM isomerase family.

Protein type: RNA-binding; Translation

Chromosomal Location of Human Ortholog: 15q25.1

Cellular Component: mitochondrion; cytoplasm; cytosol

Molecular Function: protein binding; iron-responsive element binding; translation repressor activity; RNA binding; metal ion binding; 4 iron, 4 sulfur cluster binding

Biological Process: erythrocyte homeostasis; response to retinoic acid; cellular iron ion homeostasis; negative regulation of translation; response to iron(II) ion; osteoclast differentiation; iron ion transport; protoporphyrinogen IX biosynthetic process; intestinal absorption; aging; post-embryonic development