POSTN recombinant protein

Recombinant Human POSTN protein

Cat. Num. AAA1561166

• Gene Names: POSTN; PN; OSF2; OSF-2; PDLPOSTN; periostin
• Purity: >90% as determined by SDS-PAGE
• Synonyms: POSTN; Recombinant Human POSTN protein; Periostin; PN; Osteoblast-specific factor 2; OSF-2; POSTN recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human POSTN (Asn22-Gln781) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for POSTN recombinant protein

Periostin (POSTN), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the adult, Postn expression is specifically induced in areas of tissue injury or areas with ongoing cellular re-organization. In the adult heart Postn is induced in the ventricles following myocardial infarction, pressure overload stimulation, or generalized cardiomyopathy. Although the detailed function of Postn is still unclear, Postn-integrin interaction is thought to be involved in tumor development. Postn is frequently overexpressed in various types of human cancers, stimulating metastatic growth by promoting cancer cell survival, invasion and angiogenesis, and can be a useful marker to predict the behavior of cancer.

Product Categories/Family for POSTN recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 209862907
• NCBI GeneID: 10631
• NCBI Accession #: NP_006466.2
• NCBI GenBank Nucleotide #: NM_006475.2
• UniProt Accession #: Q15063; Q15064; Q29XZ0; Q3KPJ5; Q5VSY5; Q8IZF9; B1ALD8; C0IMJ1; C0IMJ2; C0IMJ4; D2KRH7; F5H628
• Molecular Weight: 93,314 Da
• NCBI Official Full Name: periostin isoform 1
• NCBI Official Synonym Full Names: periostin, osteoblast specific factor
• NCBI Official Symbol: POSTN
• NCBI Official Synonym Symbols: PN; OSF2; OSF-2; PDLPOSTN; periostin
• NCBI Protein Information: periostin; periodontal ligament-specific periostin; osteoblast specific factor 2 (fasciclin I-like)
• UniProt Protein Name: Periostin
• Protein Family: Periostin
• UniProt Gene Name: POSTN
• UniProt Synonym Gene Names: OSF2; PN; OSF-2
• UniProt Entry Name: POSTN_HUMAN

NCBI Description

This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Uniprot Description

POSTN: Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Cell adhesion; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13q13.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; trans-Golgi network

Molecular Function: heparin binding; protein binding; cell adhesion molecule binding

Biological Process: tissue development; extracellular matrix organization and biogenesis; regulation of Notch signaling pathway; cell adhesion; skeletal development